反应条件
1: 84 percent / formic acid / 24 h / 40 °C
2: 91 percent / toluene / 16 °C / Heating
3: 1) t-butyllithium / 1) THF, pentane, -100 deg C, 0.5 h, 2) THF, pentane, -100 deg C, 0.5 h
4: hidrazine / aq. ethanol; acetic acid / 50 °C
5: 2.) NaBH4 / 1) MeOH, RT, 0.2 h, 2) MeOH, 1 h
6: 90 percent / hydrogen / 4percent Pd/C / methanol; acetic acid / 2585.7 Torr / Ambient temperature
7: determination of e.e. (86percent)
View Scheme
参考文献
Meyers; Dickman; Boes
Tetrahedron, 1987 , vol. 43, # 21 p. 5095-5108
