2-氨基-5-甲氧基苯甲醛合成路线 （共 10 条）
反应条件
palladium on carbon; hydrogen in ethyl acetate T=30°C; 6 h;
参考文献
Ren, Lei; Lei, Tao; Ye, Jia-Xi; Gong, Liu-Zhu
Angewandte Chemie - International Edition, 2012 , vol. 51, # 3 p. 771 - 774
参考文献
Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5810 - 5831
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C 2: hydrogenchloride; iron / ethanol; water / 2 h / 95 °C View Scheme
参考文献
Ren, Lei; Lei, Tao; Ye, Jia-Xi; Gong, Liu-Zhu
Angewandte Chemie - International Edition, 2012 , vol. 51, # 3 p. 771 - 774
反应条件
1: borane-THF / tetrahydrofuran / 0 °C / Reflux 2: dipyridinium dichromate / dichloromethane / 16 h / 20 °C 3: hydrogen; sodium acetate; 20 PtO2/C / ethyl acetate / 0.5 h / 20 °C View Scheme
参考文献
BIOGEN IDEC MA INC.; THOMAS, Jermaine; MI, Sha; LIN, Edward, Yin-shiang; ZHENG, Guo, Zhu; MA, Bin; CALDWELL, Richard, D.; GUCKIAN, Kevin; KUMARAVEL, Gnanasambandam
Patent: WO2012/109108 A1, 2012 ;
WO 2012/109108 A1
反应条件
1: dipyridinium dichromate / dichloromethane / 16 h / 20 °C 2: hydrogen; sodium acetate; 20 PtO2/C / ethyl acetate / 0.5 h / 20 °C View Scheme
参考文献
BIOGEN IDEC MA INC.; THOMAS, Jermaine; MI, Sha; LIN, Edward, Yin-shiang; ZHENG, Guo, Zhu; MA, Bin; CALDWELL, Richard, D.; GUCKIAN, Kevin; KUMARAVEL, Gnanasambandam
Patent: WO2012/109108 A1, 2012 ;
WO 2012/109108 A1
反应条件
1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 30 °C / |Inert atmosphere 2: manganese(IV) oxide / dichloromethane / 23 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5810 - 5831
反应条件
sodium hydroxide; ethanol
参考文献
Troeger; Cohaus
Journal fuer Praktische Chemie (Leipzig), 1927 , vol. <2> 117, p. 104
反应条件
1: t-BuONO; HBr 2: CuBr View Scheme
参考文献
Tsoungas, Petros G; Searcey, Mark
Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6589 - 6592
反应条件
1.1: t-BuONO; HBr
2.1: CuBr
3.1: TSA / benzene / 24 h / Heating
4.1: tetrahydrofuran / -78 °C
4.2: 76 percent / tetrahydrofuran
5.1: 81 percent / HCl / 12 h
View Scheme
参考文献
Tsoungas, Petros G; Searcey, Mark
Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6589 - 6592
反应条件
1: t-BuONO; HBr
2: CuBr
3: TSA / benzene / 24 h / Heating
View Scheme
参考文献
Tsoungas, Petros G; Searcey, Mark
Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6589 - 6592
