2-氨基-4-甲基苯甲腈合成路线 （共 24 条）
反应条件
hydrazine hydrate in ethanol T=78°C; 25 h;
参考文献
Chan, Sharon Lai-Fung; Low, Kam-Hung; So, Gary Kwok-Ming; Chui, Stephen Sin-Yin; Che, Chi-Ming
Chemical Communications, 2011 , vol. 47, # 31 p. 8808 - 8810
反应条件
1: 70 percent 2: 87 percent / iron; acetic acid / ethanol View Scheme
参考文献
Chandler, Stephen A.
Journal of the Chemical Society, Perkin Transactions 2, 2001 , # 2 p. 214 - 228
参考文献
Borsche; Herbert
Justus Liebigs Annalen der Chemie, 1941 , vol. 546, p. 277,291
反应条件
2: tin; concentrated hydrochloric acid; glacial acetic acid / 55 - 60 °C View Scheme
参考文献
Morgan; Coulson
Journal of the Chemical Society, 1929 , p. 2557
参考文献
Morgan; Coulson
Journal of the Chemical Society, 1929 , p. 2557
反应条件
1: Diazotization.durch Austausch von NH2 gegen CN 2: hydrochloric acid / 140 °C View Scheme
参考文献
Niementowski
Monatshefte fuer Chemie, 1891 , vol. 12, p. 625
参考文献
Borsche; Herbert
Justus Liebigs Annalen der Chemie, 1941 , vol. 546, p. 277,291
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2940 - 2948
反应条件
potassium hydroxide in ethanol 24 h; RefluxInert atmosphere;
参考文献
Cheng, Xu; Vellalath, Sreekumar; Goddard, Richard; List, Benjamin
Journal of the American Chemical Society, 2008 , vol. 130, # 47 p. 15786 - 15787
反应条件
1: potassium hydroxide / ethanol / 8 h / |Reflux 2: 6 h / 100 °C 3: acetic acid; bromine / methanol / 5 h / 20 °C View Scheme
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
