2,3,7,8,12,13,17,18-八乙基-21H,23H-卟吩合成路线 （共 40 条）
反应条件
in acetic acid 1 h; Heating; Yield given;
参考文献
Tang; Verkade
Journal of Organic Chemistry, 1994 , vol. 59, # 25 p. 7793 - 7802
反应条件
1: p-TsOH / benzene; H2O / 7 h / Heating 2: 0.99 g / O2 / benzene; H2O / 24 h View Scheme
参考文献
Milgram, Benjamin C.; Eskildsen, Katrine; Richter, Steven M.; Scheidt, W. Robert; Scheidt, Karl A.
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3941 - 3944
反应条件
1: 99 percent / KOH / ethanol; H2O / 0.33 h / 20 °C 2: p-TsOH / benzene; H2O / 7 h / Heating 3: 0.99 g / O2 / benzene; H2O / 24 h View Scheme
参考文献
Milgram, Benjamin C.; Eskildsen, Katrine; Richter, Steven M.; Scheidt, W. Robert; Scheidt, Karl A.
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3941 - 3944
反应条件
1: Br2, AcOH / 0.5 h 2: KOH / 4 h / Heating 3: O2, AcOH View Scheme
参考文献
Cheng, Lingjiang; Ma, Jinshi
Organic Preparations and Procedures International, 1995 , vol. 27, # 2 p. 224 - 228
反应条件
1: 88 percent / sodium metaperiodate / methanol; H2O / Ambient temperature 2: 2M KOH / methanol / 0.17 h / Heating 3: 1.) HCO2H; 2.) O2 / 1.) MeOH, r.t., 2 h; 2.) CH2Cl2, r.t., 3 h View Scheme
参考文献
Kinoshita; Tanaka; Nishimori; Dejima; Inomata
Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 10 p. 2660 - 2667
反应条件
1: 2M KOH / methanol / 0.17 h / Heating 2: 1.) HCO2H; 2.) O2 / 1.) MeOH, r.t., 2 h; 2.) CH2Cl2, r.t., 3 h View Scheme
参考文献
Kinoshita; Tanaka; Nishimori; Dejima; Inomata
Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 10 p. 2660 - 2667
反应条件
1: 92 percent / Zn, conc. HCl / ethanol / 0.83 h / 65 - 70 °C 2: Br2, K2CO3 / CH2Cl2; diethyl ether / 0.33 h / Ambient temperature 3: CH2Cl2; diethyl ether / 0.5 h / Ambient temperature 4: 1.) KOH, 2.) AcOH, O2 / 1.) aq. EtOH, reflux, 3 h, 2.) aq. EtOH, reflux, 1.5 h View Scheme
参考文献
Cheng, Lingjiang; Ma, Jinshi
Organic Preparations and Procedures International, 1995 , vol. 27, # 2 p. 224 - 228
反应条件
1: CH2Cl2; diethyl ether / 0.5 h / Ambient temperature 2: 1.) KOH, 2.) AcOH, O2 / 1.) aq. EtOH, reflux, 3 h, 2.) aq. EtOH, reflux, 1.5 h View Scheme
参考文献
Cheng, Lingjiang; Ma, Jinshi
Organic Preparations and Procedures International, 1995 , vol. 27, # 2 p. 224 - 228
反应条件
1: tetrahydrofuran / -100 - -78 °C 2: pyridinium p-toluenesulfonate / 1,2-dichloro-ethane / 2 h / Heating 3: 88 percent / sodium metaperiodate / methanol; H2O / Ambient temperature 4: 2M KOH / methanol / 0.17 h / Heating 5: 1.) HCO2H; 2.) O2 / 1.) MeOH, r.t., 2 h; 2.) CH2Cl2, r.t., 3 h View Scheme
参考文献
Kinoshita, Hideki; Tanaka, Shingo; Inomata, Katsuhiko
Chemistry Letters, 1989 , p. 1107 - 1108
反应条件
1: 86 percent / 1,4-diazabicyclo<5.4.0>undecene-7 / tetrahydrofuran / 10 h / Ambient temperature View Scheme
参考文献
Ono, Noboru; Maruyama, Kazuhiro
Chemistry Letters, 1988 , # 9 p. 1511 - 1514
