(S)-(-)-2-溴-3-甲基丁酸合成路线 （共 8 条）
反应条件
hydrogenchloride; sodium nitrite in water
参考文献
Lerchen, Hans-Georg; Kunz, Horst
Tetrahedron Letters, 1985 , vol. 26, # 43 p. 5257 - 5260
反应条件
1: 84 percent / triethylamine / CH2Cl2 / 4 h / 0 °C 2: 2 N aq. HCl / acetic acid / 4 h / 120 °C View Scheme
参考文献
Camps, Pelayo; Perez, Francesc; Soldevilla, Nuria
Tetrahedron Asymmetry, 1997 , vol. 8, # 11 p. 1877 - 1894
反应条件
1: 95 percent / DMAP, DCC / CH2Cl2 / 0 - 20 °C 2: n-BuLi, iPr2NH / tetrahydrofuran; hexane / 6 h / -70 - 20 °C 3: N-bromosuccinimide / tetrahydrofuran / 1 h / -70 °C 4: 30percent aq. H2O2, LiOH / tetrahydrofuran / 0.5 h View Scheme
参考文献
Angibaud, P.; Chaumette, J. L.; Desmurs, J. R.; Duhamel, L.; Ple, G.; et al.
Tetrahedron: Asymmetry, 1995 , vol. 6, # 8 p. 1919 - 1932
反应条件
1: n-BuLi, iPr2NH / tetrahydrofuran; hexane / 6 h / -70 - 20 °C 2: N-bromosuccinimide / tetrahydrofuran / 1 h / -70 °C 3: 30percent aq. H2O2, LiOH / tetrahydrofuran / 0.5 h View Scheme
参考文献
Angibaud, P.; Chaumette, J. L.; Desmurs, J. R.; Duhamel, L.; Ple, G.; et al.
Tetrahedron: Asymmetry, 1995 , vol. 6, # 8 p. 1919 - 1932
反应条件
1: N-bromosuccinimide / tetrahydrofuran / 1 h / -70 °C 2: 30percent aq. H2O2, LiOH / tetrahydrofuran / 0.5 h View Scheme
参考文献
Angibaud, P.; Chaumette, J. L.; Desmurs, J. R.; Duhamel, L.; Ple, G.; et al.
Tetrahedron: Asymmetry, 1995 , vol. 6, # 8 p. 1919 - 1932
反应条件
durch fraktionierte Krystallisation des Cinchonidinsalzes aus Aceton;
参考文献
Senoh
Yakugaku Zasshi, 1951 , vol. 71, p. 798
Chem.Abstr., 1952 , p. 2501
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran 0.5 h; Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Angibaud, P.; Chaumette, J. L.; Desmurs, J. R.; Duhamel, L.; Ple, G.; et al.
Tetrahedron: Asymmetry, 1995 , vol. 6, # 8 p. 1919 - 1932
反应条件
1.1: Inert atmosphere 2.1: tetrahydrofuran; N,N'-dimethyl-N,N'-propyleneurea; indium(III) chloride; indium; chloro-trimethyl-silane; triethylamine / 10 - 30 °C / Inert atmosphere; Sonication 2.2: Saturated solution View Scheme
参考文献
Ishihara, Jun; Watanabe, Yuki; Koyama, Noriko; Nishino, Yukihiro; Takahashi, Keisuke; Hatakeyama, Susumi
Tetrahedron, 2011 , vol. 67, # 20 p. 3659 - 3667
