2-氨基羰基-5-硝基苯并呋喃合成路线 （共 8 条）
反应条件
ammonia in ethanol T=20°C; Aminolysis; 24 h;
参考文献
Coates, Philippa A.; Grundt, Peter; Robinson, Emma S.J.; Nutt, David J.; Tyacke, Robin; Hudson, Alan L.; Lewis, John W.; Husbands, Stephen M.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 6 p. 605 - 607
反应条件
1: With thionyl chloride; N,N-dimethyl-formamide in toluene T=35 - 115°C; 2: With ammonia T=10°C; pH=8 - 9;
参考文献
DWIVEDI, Shriprakash Dhar; Singh, Ramesh Chandra; Patil, Sachin Ashokrao
Patent: US2014/179713 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
1: 84 percent / K2CO3; Bu4NBr / toluene / 24 h / Heating 2: 99 percent / NH3 / ethanol / 24 h / 20 °C View Scheme
参考文献
Coates, Philippa A.; Grundt, Peter; Robinson, Emma S.J.; Nutt, David J.; Tyacke, Robin; Hudson, Alan L.; Lewis, John W.; Husbands, Stephen M.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 6 p. 605 - 607
反应条件
1.1: sulfuric acid; nitric acid / 5 - 35 °C 2.1: acetic anhydride / 0.25 h / 35 °C 2.2: 8 h / 125 °C 3.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 35 - 115 °C 3.2: 10 °C / pH 8 - 9 View Scheme
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash Dhar; SINGH, Ramesh Chandra; CHAVDA, Rajendra Gokalbhai
Patent: WO2013/175499 A2, 2013 ;
反应条件
1.1: sodium hydroxide / water / 3 h / 30 - 100 °C 2.1: sulfuric acid; nitric acid / 5 - 35 °C 3.1: acetic anhydride / 0.25 h / 35 °C 3.2: 8 h / 125 °C 4.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 35 - 115 °C 4.2: 10 °C / pH 8 - 9 View Scheme
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash Dhar; SINGH, Ramesh Chandra; CHAVDA, Rajendra Gokalbhai
Patent: WO2013/175499 A2, 2013 ;
反应条件
1.1: acetic anhydride / 0.25 h / 35 °C 1.2: 8 h / 125 °C 2.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 35 - 115 °C 2.2: 10 °C / pH 8 - 9 View Scheme
参考文献
DWIVEDI, Shriprakash Dhar; Singh, Ramesh Chandra; Patil, Sachin Ashokrao
Patent: US2014/179713 A1, 2014 ;
反应条件
1: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 2: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 3: hydrogen bromide; 4-hydroxy-benzoic acid / acetic acid / 50 °C 4: triethylamine / acetonitrile / 48 h / 35 - 80 °C View Scheme
参考文献
RANBAXY LABORATORIES LIMITED; DAS, Prasenjit; SRIVASTAVA, Bindu; MAHESHWARI, Nitin; MEERAN, Hashim, Nizar, Poovanathil, Nagoor; PRASAD, Mohan; ARORA, Sudershan, Kumar
Patent: WO2014/61004 A2, 2014 ;
反应条件
1: hydrogen / methanol / 14 h / 35 - 60 °C / 4500.45 Torr 2: N-ethyl-N,N-diisopropylamine / 10 h / 120 °C 3: hydrogen bromide; 4-hydroxy-benzoic acid / acetic acid / 50 °C View Scheme
