3-甲基-2-丁烯-1-胺盐酸盐(1:1)合成路线 （共 11 条）
反应条件
1: With hydrazine in ethanol 1 h; Reflux; 2: With hydrogenchloride in ethanol; water 1 h; Reflux;
参考文献
Coxon, Geoffrey D.; Furman, Brian L.; Harvey, Alan L.; McTavish, John; Mooney, Mark H.; Arastoo, Mahmoud; Kennedy, Alan R.; Tettey, Justice M.; Waigh, Roger D.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 11 p. 3457 - 3463
反应条件
hydrogenchloride; anhydrous guanidine 1) EtOH, 1 h; Yield given. Multistep reaction;
参考文献
Crombie, Leslie; Jarrett, Sandra R. M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 23 p. 3179 - 3184
反应条件
Yield given. Multistep reaction;
参考文献
Murahashi, Shun-Ichi; Tanigawa, Yoshio; Imada, Yasushi; Taniguchi, Yuki
Tetrahedron Letters, 1986 , vol. 27, # 2 p. 227 - 230
反应条件
potassium carbonate in butan-1-ol T=110°C; 5 h; chemoselective reaction;
参考文献
Corder, Andra L.; Subedi, Bishnu P.; Zhang, Siai; Dark, Amanda M.; Foss Jr., Frank W.; Pierce, Brad S.
Biochemistry, 2013 , vol. 52, # 36 p. 6182 - 6196
反应条件
triethylamine in propan-1-ol T=100°C; 4 h;
参考文献
Mik, Vaclav; Szuecova, Lucie; Spichal, Lukas; Plihal, Ondrej; Nisler, Jaroslav; Zahajska, Lenka; Dolezal, Karel; Strnad, Miroslav
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 23 p. 7244 - 7251
反应条件
1.1: potassium carbonate / butan-1-ol / 5 h / 110 °C 2.1: iso-propylmagnesium bromide; bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 24 h / |Reflux 2.2: 0 °C View Scheme
参考文献
Corder, Andra L.; Subedi, Bishnu P.; Zhang, Siai; Dark, Amanda M.; Foss Jr., Frank W.; Pierce, Brad S.
Biochemistry, 2013 , vol. 52, # 36 p. 6182 - 6196
反应条件
1.1: potassium carbonate / butan-1-ol / 5 h / 110 °C 2.1: iso-propylmagnesium bromide; bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 24 h / |Reflux 2.2: 0 °C 3.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 18 h / |Reflux 4.1: sodium methylate; methanol / 6 h / 20 °C View Scheme
参考文献
Corder, Andra L.; Subedi, Bishnu P.; Zhang, Siai; Dark, Amanda M.; Foss Jr., Frank W.; Pierce, Brad S.
Biochemistry, 2013 , vol. 52, # 36 p. 6182 - 6196
反应条件
1.1: potassium carbonate / butan-1-ol / 5 h / 110 °C 2.1: iso-propylmagnesium bromide; bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 24 h / |Reflux 2.2: 0 °C 3.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 18 h / |Reflux 4.1: sodium methylate; methanol / 6 h / 20 °C 5.1: Salmonella typhimurium O2-dependent tRNA modifying monooxgenase; dihydrogen peroxide / dimethyl sulfoxide / 1 h / 27 °C / pH 8 / |Enzymatic reaction View Scheme
参考文献
Corder, Andra L.; Subedi, Bishnu P.; Zhang, Siai; Dark, Amanda M.; Foss Jr., Frank W.; Pierce, Brad S.
Biochemistry, 2013 , vol. 52, # 36 p. 6182 - 6196
反应条件
1.1: potassium carbonate / butan-1-ol / 5 h / 110 °C 2.1: iso-propylmagnesium bromide; bis(cyclopentadienyl)titanium dichloride / tetrahydrofuran / 24 h / |Reflux 2.2: 0 °C 3.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 18 h / |Reflux 4.1: sodium methylate; methanol / 6 h / 20 °C View Scheme
参考文献
Corder, Andra L.; Subedi, Bishnu P.; Zhang, Siai; Dark, Amanda M.; Foss Jr., Frank W.; Pierce, Brad S.
Biochemistry, 2013 , vol. 52, # 36 p. 6182 - 6196
参考文献
Desvages,G.; Olomucki,M.
Bulletin de la Societe Chimique de France, 1969 , p. 3229 - 3232
