1,2-双(溴甲基)-4,5-二甲氧基苯合成路线 （共 8 条）
反应条件
hydrogen bromide in acetic acid 1.) room temp., 20 h; 2.) 65 deg C, 1 h;
参考文献
MERCK SHARP and DOHME CORP.; SHUMWAY, Stuart Denham; TONIATTI, Carlo; ROBERTS, Brian Scott; MARTIN, Melissa M.
Patent: WO2013/39854 A1, 2013 ;
Location in patent: Page/Page column 38 ;
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane 1 h; Molecular sieveUV-irradiationInert atmosphereReflux;
参考文献
Chebny, Vincent J.; Shukla, Ruchi; Lindeman, Sergey V.; Rathore, Rajendra
Organic Letters, 2009 , vol. 11, # 9 p. 1939 - 1942
反应条件
hydrogen bromide 17 h; Ambient temperature;
参考文献
Abou-Teim, Omar; Jansen, Robert B.; McOmie, John F. W.; Perry, David H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1841 - 1846
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 3 h; Heating;
参考文献
Abou-Teim, Omar; Jansen, Robert B.; McOmie, John F. W.; Perry, David H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1841 - 1846
反应条件
1: LiAlH4 / tetrahydrofuran 2: PBr3 / benzene View Scheme
参考文献
Taylor; Lewis; Jacklin
Journal of medicinal chemistry, 1970 , vol. 13, # 6 p. 1226 - 1227
反应条件
hydrogen bromide 18 h; Ambient temperature;
参考文献
Abou-Teim, Omar; Jansen, Robert B.; McOmie, John F. W.; Perry, David H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1841 - 1846
反应条件
1: 10 percent 2: LiAlH4 3: 42 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating View Scheme
参考文献
Abou-Teim, Omar; Jansen, Robert B.; McOmie, John F. W.; Perry, David H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1841 - 1846
反应条件
sodium ethanolate in N,N-dimethyl-formamide
T=80°C; 5 h;
参考文献
Dalence-Guzman, Maria F.; Berglund, Magnus; Skogvall, Staffan; Sterner, Olov
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 5 p. 2499 - 2512
