7-氯-3,4-二氢-2H-1-萘酮合成路线 （共 23 条）
反应条件
1: tin (II)-chloride; hydrochloric acid 2: Diazotization.Behandeln mit Kupfer(I)-chlorid View Scheme
参考文献
v. Braun
Justus Liebigs Annalen der Chemie, 1927 , vol. 451, p. 53
反应条件
1: HNO3+H2SO4 / -10 °C 2: tin (II)-chloride; hydrochloric acid 3: Diazotization.Behandeln mit Kupfer(I)-chlorid View Scheme
参考文献
v. Braun
Justus Liebigs Annalen der Chemie, 1927 , vol. 451, p. 53
参考文献
Strehlke; Hoyer; Schroeder
Archiv der Pharmazie, 1975 , vol. 308, # 2 p. 94 - 109
参考文献
Buu-Hoi et al.
Journal of the Chemical Society, 1952 , p. 279
反应条件
1: 1.8 g / O2, K / 2-methyl-propan-2-ol / 4 h / Ambient temperature 2: 1.0 g / conc. HCl / 3 h / Heating 3: 1.) SnCl2, conc. HCl; 2.) 50percent KOH / 1.) EtOH, r.t., 1 h; 2.) reflux, 1 h 4: 2 mg / NaBH4, PdCl2 / methanol / 1 h / Ambient temperature 5: 393 mg / BBr3 / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Inoue, Kenichiro; Ueda, Shinichi; Nayeshiro, Hidekazu; Moritome, Nobuharu; Inouye, Hiroyuki
Phytochemistry (Elsevier), 1984 , vol. 23, # 2 p. 313 - 318
反应条件
1: (i), (ii) (dehydration), (iii) DDQ
2: 230 °C
View Scheme
参考文献
Leznoff,C.C.; Hayward,R.J.
Canadian Journal of Chemistry, 1970 , vol. 48, p. 1842 - 1849
反应条件
(i) Al(OiPr)3, (ii) KHSO4; Multistep reaction;
参考文献
Jackman,L.M.; Thompson,D.T.
Journal of the Chemical Society, 1961 , p. 4794 - 4808
参考文献
Baddar et al.
Journal of the Chemical Society, 1959 , p. 1027,1029
反应条件
1: 1.8 g / O2, K / 2-methyl-propan-2-ol / 4 h / Ambient temperature
2: 1.0 g / conc. HCl / 3 h / Heating
3: 1.) SnCl2, conc. HCl; 2.) 50percent KOH / 1.) EtOH, r.t., 1 h; 2.) reflux, 1 h
4: 2 mg / NaBH4, PdCl2 / methanol / 1 h / Ambient temperature
5: 393 mg / BBr3 / CH2Cl2 / 2 h / Ambient temperature
6: 74 mg / K2CO3 / acetone / 3 h / Heating
View Scheme
参考文献
Inoue, Kenichiro; Ueda, Shinichi; Nayeshiro, Hidekazu; Moritome, Nobuharu; Inouye, Hiroyuki
Phytochemistry (Elsevier), 1984 , vol. 23, # 2 p. 313 - 318
反应条件
bromine in diethyl ether
T=10°C;
参考文献
E. R. Squibb and Sons, Inc.
Patent: US3985731 A1, 1976 ;
