5-氯-Alpha-四氢萘酮合成路线 （共 5 条）
反应条件
hydrogenchloride; copper(l) chloride; sodium nitrite in water 1 h; Ambient temperature;
参考文献
Itoh; Miyake; Tada; Hirata; Oka
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 1 p. 130 - 151
反应条件
methanesulfonic acid; phosphorous pentoxide T=0 - 20°C; 16 h; Inert atmosphere;
参考文献
Romanov-Michailidis, Fedor; Guenee, Laure; Alexakis, Alexandre
Angewandte Chemie - International Edition, 2013 , vol. 52, # 35 p. 9266 - 9270
Angew. Chem., 2013 , vol. 125, # 35 p. 9436 - 9440
反应条件
aluminium trichloride T=0 - 100°C; Fiedel-Crafts acylation; 3 h;
参考文献
Caldwell, John P.; Matasi, Julius J.; Zhang, Hongtao; Fawzi, Ahmad; Tulshian, Deen B.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2281 - 2284
参考文献
Strehlke; Hoyer; Schroeder
Archiv der Pharmazie, 1975 , vol. 308, # 2 p. 94 - 109
反应条件
1: NaBH4; PEG-400 / 65 °C
2: 84 percent / pyridine / CHCl3 / 3 h / 20 °C
3: 67 percent / K2CO3 / dimethylformamide / 1.5 h / Heating
View Scheme
参考文献
Parihar; Ramana
Tetrahedron Letters, 2003 , vol. 44, # 9 p. 1843 - 1845
