(2S)-2-氨基-4-甲基戊酸甲酯合成路线 （共 67 条）
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane
T=25°C; 0.166667 h;
参考文献
Knoelker, Hans-Joachim; Braxmeier, Tobias
Synlett, 1997 , vol. 1997, # 8 p. 925 - 928
反应条件
pyridine in dichloromethane; toluene
T=0°C; 2 h;
参考文献
Liao, Yung-Feng; Wang, Bo-Jeng; Hsu, Wen-Ming; Lee, Hsinyu; Liao, Chia-Yin; Wu, Shin-Ying; Cheng, Hui-Ting; Hu, Ming-Kuan
Molecular Pharmacology, 2007 , vol. 71, # 2 p. 588 - 601
反应条件
in 1,4-dioxane; water
参考文献
SmithKline Beecham Corporation
Patent: US5998470 A1, 1999 ;
US 5998470 A
反应条件
sodium hydrogencarbonate in water
参考文献
Curcio, Pasquale; Allix, Florent; Pickaert, Guillaume; Jamart-Gregoire, Brigitte
Chemistry - A European Journal, 2011 , vol. 17, # 48 p. 13603 - 13612
反应条件
1: (i) ClCO2Et, Et3N, CHCl3, (ii) /BRN= 1722045/
2: aq. NaOH / acetone
View Scheme
参考文献
Okumura,Y.; Sakurai,A.
Bulletin of the Chemical Society of Japan, 1973 , vol. 46, p. 2190 - 2193
反应条件
1: 85 percent / DCC / CH2Cl2 / Ambient temperature
2: 95 percent / 2N NaOH / methanol / 12 h / Ambient temperature
View Scheme
参考文献
Nagaraj, R.; Balaram, P.
Tetrahedron, 1981 , vol. 37, p. 1263 - 1270
反应条件
2: Hydrogen bromide / acetic acid
4: NH2NH2
5: HNO2
7: H2 / catalytic hydrog.
View Scheme
参考文献
Nikolaev, S. V.; Martinov, V. F.
Chemistry of Natural Compounds, 1985 , vol. 21, # 2 p. 269 - 270
Khimiya Prirodnykh Soedinenii, 1985 , # 2 p. 281 - 282
