(2S)-2-氨基-4-甲基戊酸甲酯合成路线 （共 67 条）
反应条件
α-chymotrypsin in 1,1-dimethylpropan-1-ol; water; benzene T=20°C; 48 h;
参考文献
Tetrahedron Letters, , vol. 30, # 21 p. 2787 - 2790
反应条件
1: diethyl ether 2: durch Verseifung und anschliessender Hydrogenolyse an Palladium/Kohle View Scheme
参考文献
Journal of Organic Chemistry, , vol. 15, p. 108,115
反应条件
sodium hydrogencarbonate in dichloromethane; water T=0°C; 0.25 h;
参考文献
Sunder-Plassmann, Nils; Sarli, Vasiliki; Gartner, Michael; Utz, Mathias; Seiler, Jeanette; Huemmer, Stefan; Mayer, Thomas U.; Surrey, Thomas; Giannis, Athanassios
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 22 p. 6094 - 6111
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane T=25°C; 0.166667 h;
参考文献
Knoelker, Hans-Joachim; Braxmeier, Tobias
Synlett, 1997 , vol. 1997, # 8 p. 925 - 928
反应条件
pyridine in dichloromethane; toluene T=0°C; 2 h;
参考文献
Liao, Yung-Feng; Wang, Bo-Jeng; Hsu, Wen-Ming; Lee, Hsinyu; Liao, Chia-Yin; Wu, Shin-Ying; Cheng, Hui-Ting; Hu, Ming-Kuan
Molecular Pharmacology, 2007 , vol. 71, # 2 p. 588 - 601
反应条件
1: 70 percent / N-ethyl-N'-(3-dimethylaminopropyl)-carbodiimide*HCl; N-hydroxybenzotriazole; N-methylmorpholine / dimethylformamide / 12 h / 20 °C 2: aq. NaOH / tetrahydrofuran / 10 h / 20 °C View Scheme
参考文献
Kokinaki, Stella; Leondiadis, Leondios; Ferderigos, Nikolas
Organic Letters, 2005 , vol. 7, # 9 p. 1723 - 1724
反应条件
1: methyl chloroformate 2: hydrogen / 10 percent Pd/C 3: MeOH; Et3N / Heating View Scheme
参考文献
Suzuki; Sasaki; Endo; Mihara
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 1 p. 233 - 237
反应条件
benzotriazol-1-ol; dicyclohexyl-carbodiimide
参考文献
Koenig,W.; Geiger,R.
Chemische Berichte, 1970 , vol. 103, p. 788 - 798
参考文献
Dwivedi, Shailendra Kumar Dhar; Samanta, Krishnananda; Yadav, Manisha; Jana, Amit Kumar; Singh, Abhishek Kumar; Chakravarti, Bandana; Mondal, Sankalan; Konwar, Rituraj; Trivedi, Arun Kumar; Chattopadhyay, Naibedya; Sanyal, Sabyasachi; Panda, Gautam
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6816 - 6821
反应条件
1: 73 percent / dicyclohexylcarbodiimide; 1-hydroxybenzotriazole 2: H2; HCOOH / 10 percent Pd/C / methanol / 24 h / 20 °C 3: 91 percent / NaOH / methanol / 5 h / 0 °C View Scheme
参考文献
Wang, Chao; Zhao, Ming; Cui, Weina; Yang, Jian; Peng, Shiqi
Synthetic Communications, 2003 , vol. 33, # 10 p. 1633 - 1641
