2-[2-(2-甲氧基苯氧基)乙基]-1H-异吲哚-1,3(2H)-二酮合成路线 （共 5 条）
反应条件
18-crown-6 ether in N,N-dimethyl-formamide T=50°C; Gabriel synthesis; 5 h;
参考文献
Groszek, Grazyna; Bednarski, Marek; Dybala, Malgorzata; Filipek, Barbara
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 2 p. 809 - 817
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=20°C; Mitsunobu reaction; Inert atmosphere;
参考文献
Carocci, Alessia; Catalano, Alessia; Lovece, Angelo; Lentini, Giovanni; Duranti, Andrea; Lucini, Valeria; Pannacci, Marilou; Scaglione, Francesco; Franchini, Carlo
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 17 p. 6496 - 6511
反应条件
1: aq. NaOH / 7 h / 100 °C 2: dimethylformamide / Heating View Scheme
参考文献
Liang, Jhy-Chong; Yeh, Jwu-Lai; Wang, Chia-Sui; Liou, Shwu-Fen; Tsai, Chieh-Ho; Chen, Ing-Jun
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 3 p. 719 - 730
反应条件
tetrabutylammomium bromide T=180 - 185°C; Product distribution / selectivity;
参考文献
SHODHANA LABORATORIES LIMITED
Patent: WO2009/128088 A2, 2009 ;
Location in patent: Page/Page column 10 ;
反应条件
hydrazine hydrate in water T=20°C; Gabriel synthesis; 5 h;
参考文献
Carocci, Alessia; Catalano, Alessia; Lovece, Angelo; Lentini, Giovanni; Duranti, Andrea; Lucini, Valeria; Pannacci, Marilou; Scaglione, Francesco; Franchini, Carlo
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 17 p. 6496 - 6511
