2,3,5-三氟吡啶-4-甲醛合成路线 （共 5 条）
反应条件
oxalyl dichloride; dimethyl sulfoxide in dichloromethane T=-30°C; Oxidation;
参考文献
Moon, Sin Chul; Shin, Jung-Hyu; Jeong, Bong Ho; Kim, Hee Seok; Yu, Byung Soo; Lee, Ji-Sook; Lee, Bang Sook; Namgoong, Sung Keon
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 13 p. 1435 - 1438
反应条件
1: 90 percent / NaBH4 / methanol / 0 °C 2: hydrazine / tetrahydrofuran / 50 °C 3: CuSO4; NaOH / ethanol / 30 °C 4: 78 percent / oxalyl chloride; DMSO / CH2Cl2 / -30 °C View Scheme
参考文献
Moon, Sin Chul; Shin, Jung-Hyu; Jeong, Bong Ho; Kim, Hee Seok; Yu, Byung Soo; Lee, Ji-Sook; Lee, Bang Sook; Namgoong, Sung Keon
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 13 p. 1435 - 1438
反应条件
1: hydrazine / tetrahydrofuran / 50 °C 2: CuSO4; NaOH / ethanol / 30 °C 3: 78 percent / oxalyl chloride; DMSO / CH2Cl2 / -30 °C View Scheme
参考文献
Moon, Sin Chul; Shin, Jung-Hyu; Jeong, Bong Ho; Kim, Hee Seok; Yu, Byung Soo; Lee, Ji-Sook; Lee, Bang Sook; Namgoong, Sung Keon
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 13 p. 1435 - 1438
反应条件
1: 45 percent / diisobutylaluminum hydride / hexane; diethyl ether / 0 °C 2: 90 percent / NaBH4 / methanol / 0 °C 3: hydrazine / tetrahydrofuran / 50 °C 4: CuSO4; NaOH / ethanol / 30 °C 5: 78 percent / oxalyl chloride; DMSO / CH2Cl2 / -30 °C View Scheme
参考文献
Moon, Sin Chul; Shin, Jung-Hyu; Jeong, Bong Ho; Kim, Hee Seok; Yu, Byung Soo; Lee, Ji-Sook; Lee, Bang Sook; Namgoong, Sung Keon
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 13 p. 1435 - 1438
反应条件
1: CuSO4; NaOH / ethanol / 30 °C 2: 78 percent / oxalyl chloride; DMSO / CH2Cl2 / -30 °C View Scheme
参考文献
Moon, Sin Chul; Shin, Jung-Hyu; Jeong, Bong Ho; Kim, Hee Seok; Yu, Byung Soo; Lee, Ji-Sook; Lee, Bang Sook; Namgoong, Sung Keon
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 13 p. 1435 - 1438
