(6-{2-[3-(4-苯基氨基甲酰)-5-(4-氟-苯基)-2-异丙基-4-苯基-d5-吡咯-1-基]-乙基}-2,2-二甲基-[1,3]-二恶烷-4-基)-乙酸,叔-丁酯合成路线 （共 4 条）
反应条件
1: 97 percent / toluene / 4 h / 80 °C 2: 15.26 g / β-alanine; glacial acetic acid / hexane / 25 h / Heating 3: 4.7 g / 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / 21 h / 75 - 80 °C 4: 4.07 g / pivalic acid / tetrahydrofuran; toluene; heptane / 24 h / Heating View Scheme
参考文献
Chen, Bang-Chi; Sundeen, Joseph E.; Guo, Peng; Bednarz, Mark S.; Hangeland, Jon J.; Ahmed, Syed Z.; Jemal, Mohammed
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 3 p. 261 - 270
反应条件
1: 15.26 g / β-alanine; glacial acetic acid / hexane / 25 h / Heating 2: 4.7 g / 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / 21 h / 75 - 80 °C 3: 4.07 g / pivalic acid / tetrahydrofuran; toluene; heptane / 24 h / Heating View Scheme
参考文献
Chen, Bang-Chi; Sundeen, Joseph E.; Guo, Peng; Bednarz, Mark S.; Hangeland, Jon J.; Ahmed, Syed Z.; Jemal, Mohammed
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 3 p. 261 - 270
反应条件
1: 4.7 g / 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide; triethylamine / ethanol / 21 h / 75 - 80 °C 2: 4.07 g / pivalic acid / tetrahydrofuran; toluene; heptane / 24 h / Heating View Scheme
参考文献
Chen, Bang-Chi; Sundeen, Joseph E.; Guo, Peng; Bednarz, Mark S.; Hangeland, Jon J.; Ahmed, Syed Z.; Jemal, Mohammed
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 3 p. 261 - 270
反应条件
2,2,2-trimethylacetic acid in tetrahydrofuran; n-heptane; toluene Cycloaddition; condensation; 24 h; Heating;
参考文献
Chen, Bang-Chi; Sundeen, Joseph E.; Guo, Peng; Bednarz, Mark S.; Hangeland, Jon J.; Ahmed, Syed Z.; Jemal, Mohammed
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 3 p. 261 - 270
