2-(二甲氧基膦酰基)丙酸甲酯合成路线 (共 9 条)
反应条件
1: dimethyl lt;1-(methoxycarbonyl)ethylgt;phosphonate With sodium hydride in tetrahydrofuran; mineral oil
T=0 - 40°C; Horner-Wadsworth-Emmons olefination;
2: Caprylic Aldehyde in tetrahydrofuran; mineral oil
Horner-Wadsworth-Emmons olefination; 24 h; Reflux;
3: With platinum(IV) oxide; hydrogen in methanol
参考文献
Nawrath, Thorben; Gerth, Klaus; Mueller, Rolf; Schulz, Stefan
Chemistry and Biodiversity, 2010 , vol. 7, # 9 p. 2228 - 2253
反应条件
1: dimethyl lt;1-(methoxycarbonyl)ethylgt;phosphonate With sodium hydride in tetrahydrofuran; mineral oil
T=0 - 40°C; Horner-Wadsworth-Emmons olefination;
2: pentanal in tetrahydrofuran; mineral oil
Horner-Wadsworth-Emmons olefination; 24 h; Reflux; optical yield given as percent de;
参考文献
Nawrath, Thorben; Gerth, Klaus; Mueller, Rolf; Schulz, Stefan
Chemistry and Biodiversity, 2010 , vol. 7, # 9 p. 2228 - 2253
反应条件
1: dimethyl lt;1-(methoxycarbonyl)ethylgt;phosphonate With sodium hydride in tetrahydrofuran; mineral oil
T=0 - 40°C; Horner-Wadsworth-Emmons olefination;
2: Decanaldehyde in tetrahydrofuran; mineral oil
Horner-Wadsworth-Emmons olefination; 24 h; Reflux;
3: With platinum(IV) oxide; hydrogen in methanol
参考文献
Nawrath, Thorben; Gerth, Klaus; Mueller, Rolf; Schulz, Stefan
Chemistry and Biodiversity, 2010 , vol. 7, # 9 p. 2228 - 2253
反应条件
1: dimethyl lt;1-(methoxycarbonyl)ethylgt;phosphonate With sodium hydride in tetrahydrofuran; mineral oil
T=0 - 40°C; Horner-Wadsworth-Emmons olefination;
2: 1-dodecanal in tetrahydrofuran; mineral oil
Horner-Wadsworth-Emmons olefination; 24 h; Reflux;
3: With platinum(IV) oxide; hydrogen in methanol
参考文献
Nawrath, Thorben; Gerth, Klaus; Mueller, Rolf; Schulz, Stefan
Chemistry and Biodiversity, 2010 , vol. 7, # 9 p. 2228 - 2253
反应条件
1: dimethyl lt;1-(methoxycarbonyl)ethylgt;phosphonate With sodium hydride in tetrahydrofuran; mineral oil
T=0 - 40°C; Horner-Wadsworth-Emmons olefination;
2: heptanal in tetrahydrofuran; mineral oil
Horner-Wadsworth-Emmons olefination; 24 h; Reflux;
3: With platinum(IV) oxide; hydrogen in methanol
参考文献
Nawrath, Thorben; Gerth, Klaus; Mueller, Rolf; Schulz, Stefan
Chemistry and Biodiversity, 2010 , vol. 7, # 9 p. 2228 - 2253
反应条件
1: dimethyl lt;1-(methoxycarbonyl)ethylgt;phosphonate With sodium hydride in tetrahydrofuran; mineral oil
T=0 - 40°C; Horner-Wadsworth-Emmons olefination;
2: pentanal in tetrahydrofuran; mineral oil
Horner-Wadsworth-Emmons olefination; 24 h; Reflux;
3: With platinum(IV) oxide; hydrogen in methanol
参考文献
Nawrath, Thorben; Gerth, Klaus; Mueller, Rolf; Schulz, Stefan
Chemistry and Biodiversity, 2010 , vol. 7, # 9 p. 2228 - 2253
反应条件
1: dimethyl lt;1-(methoxycarbonyl)ethylgt;phosphonate With sodium hydride in tetrahydrofuran; mineral oil
T=0 - 40°C; Horner-Wadsworth-Emmons olefination;
2: methylundecylketone in tetrahydrofuran; mineral oil
Horner-Wadsworth-Emmons olefination; 24 h; Reflux;
3: With platinum(IV) oxide; hydrogen in methanol
参考文献
Nawrath, Thorben; Gerth, Klaus; Mueller, Rolf; Schulz, Stefan
Chemistry and Biodiversity, 2010 , vol. 7, # 9 p. 2228 - 2253
反应条件
1: dimethyl lt;1-(methoxycarbonyl)ethylgt;phosphonate With sodium hydride in tetrahydrofuran; mineral oil
T=0 - 40°C; Horner-Wadsworth-Emmons olefination;
2: pelargonaldehyde in tetrahydrofuran; mineral oil
Horner-Wadsworth-Emmons olefination; 24 h; Reflux;
3: With platinum(IV) oxide; hydrogen in methanol
参考文献
Nawrath, Thorben; Gerth, Klaus; Mueller, Rolf; Schulz, Stefan
Chemistry and Biodiversity, 2010 , vol. 7, # 9 p. 2228 - 2253
反应条件
1: dimethyl lt;1-(methoxycarbonyl)ethylgt;phosphonate With sodium hydride in tetrahydrofuran; mineral oil
T=0 - 40°C; Horner-Wadsworth-Emmons olefination;
2: pentylpentylketone in tetrahydrofuran; mineral oil
Horner-Wadsworth-Emmons olefination; 24 h; Reflux;
3: With platinum(IV) oxide; hydrogen in methanol
参考文献
Nawrath, Thorben; Gerth, Klaus; Mueller, Rolf; Schulz, Stefan
Chemistry and Biodiversity, 2010 , vol. 7, # 9 p. 2228 - 2253