(4-溴苯甲酰)乙酸乙酯合成路线 （共 15 条）
反应条件
1: iodine; copper(II) oxide / ethanol / 78 °C 2: iodine; copper(II) oxide / ethanol / 78 °C View Scheme
参考文献
Zhu, Yan-Ping; Yuan, Jing-Jing; Zhao, Qin; Lian, Mi; Gao, Qing-He; Liu, Mei-Cai; Yang, Yan; Wu, An-Xin
Tetrahedron, 2012 , vol. 68, # 1 p. 173 - 178
反应条件
1: 16 h 2: water; sodium carbonate / |Reflux View Scheme
参考文献
Wang, Teng; Jiao, Ning
Journal of the American Chemical Society, 2013 , vol. 135, # 32 p. 11692 - 11695
参考文献
Belzecki; Urbanski
Roczniki Chemii, 1958 , vol. 32, p. 779,783, 785
Chem.Abstr., 1959 , p. 10187
反应条件
1.1: sodium nitrite / tetrahydrofuran; acetic acid; water / 3 h / 6 - 9 °C / |Large scale
2.1: zinc / acetic acid; water; ethanol / 2.25 h / -5 - 20 °C / |Inert atmosphere
2.2: 16 h / -9 - 20 °C
3.1: potassium carbonate / water; acetone / 4.2 h / 30 - 34.1 °C / |Inert atmosphere
View Scheme
参考文献
Magnus, Nicholas A.; Staszak, Michael A.; Udodong, Uko E.; Wepsiec, James P.
Organic Process Research and Development, 2006 , vol. 10, # 5 p. 899 - 904
反应条件
N-bromosuccinmide in dichloromethane
18 h;
参考文献
ENANTA PHARMACEUTICALS, INC.; QIU, Yao-Ling; WANG, Ce; PENG, Xiaowen; YING, Lu; CAO, Hui; OR, Yat, Sun
Patent: WO2011/91417 A1, 2011 ;
Location in patent: Page/Page column 77-78 ;
