N-ethyl-N,N-diisopropylamine in isopropyl alcohol 3 h; Inert atmosphereRefluxLarge scale; regioselective reaction;

in ethyl acetate

暂无反应条件数据

1: toluene-4-sulfonic acid / ethyl acetate / 2 h / 50 - 62 °C / |Inert atmosphere; |Large scale 2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 3 h / |Inert atmosphere; |Reflux; |Large scale View Scheme

1: toluene-4-sulfonic acid / ethyl acetate / 2 h / 50 - 62 °C / |Inert atmosphere; |Large scale 2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 3 h / |Inert atmosphere; |Reflux; |Large scale View Scheme

triethylamine; tetrakis(triphenylphosphine) palladium(0) in DMF (N,N-dimethyl-formamide) T=100°C; 6 h;

triethylamine; tetrakis (triphenylphosphine) palladium (0) in N,N-dimethyl-formamide

tetrakis(triphenylphosphine) palladium(0); triethylamine in N,N-dimethyl-formamide T=80 - 82°C; P=7500.75 Torr; 21 h; AutoclaveInert atmosphereLarge scale;

1.1: triethylamine; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 21 h / 80 - 82 °C / 7500.75 Torr / |Autoclave; |Inert atmosphere; |Large scale 1.2: 2 h / |Reflux; |Large scale 2.1: tetrahydrofuran / 3 h / 22 °C / |Large scale 3.1: tetrahydrofuran / 1.5 h / 20 °C / |Large scale 4.1: trifluoroacetic acid / water; isopropyl alcohol / 2 h / pH 9.8 - 10 / |Reflux; |Large scale View Scheme

1.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; sodium carbonate / 105 °C / 15001.5 Torr / Autoclave 2.1: trifluoroacetic acid / ethanol / 20 h / 50 °C / Inert atmosphere 3.1: 4-methyl-morpholine / ethylene glycol dimethyl ether / 50 - 60 °C / Inert atmosphere; Large scale reaction 4.1: ethylene glycol dimethyl ether / 1.75 h / 65 °C / Inert atmosphere; Large scale reaction 5.1: ethanol; 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 °C / Inert atmosphere 6.1: sulfuric acid / acetone / 0.83 h / 20 °C / Inert atmosphere; Large scale reaction 7.1: sodium hypochlorite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; tetraethylammonium bromide; sodium hydrogencarbonate / dichloromethane / 2 - 5 °C / Inert atmosphere 7.2: Inert atmosphere 8.1: dichloromethane / 20 °C / Inert atmosphere; Large scale reaction 9.1: dichloromethane / -15 - 0 °C / Inert atmosphere 10.1: sodium hydroxide / methanol; water / 5 - 40 °C / Inert atmosphere; Large scale reaction 10.2: pH 1 - 2 / Inert atmosphere; Large scale reaction 11.1: dichloromethane / 2 h / 20 °C / Inert atmosphere; Large scale reaction 12.1: triethylamine / dichloromethane / -10 °C / Inert atmosphere; Large scale reaction 13.1: methanesulfonic acid; water / 10 h / 70 °C / Inert atmosphere; Large scale reaction 13.2: Inert atmosphere; Large scale reaction View Scheme