2-氨基-5-(4-氯苯基)-呋喃-3-甲腈合成路线 (共 5 条)
反应条件
diethylamine in DMF (N,N-dimethyl-formamide) T=0 - 40°C; 3.5 h;
参考文献
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; JEIL PHARMACEUTICAL CO., LTD.
Patent: WO2005/92896 A1, 2005 ;
Location in patent: Page/Page column 34; 36 ;
WO 2005/092896 A1
反应条件
hydrogenchloride in acetic acid 1 h; Heating;
参考文献
Abdelhamid, Abdou O.; Negm, Abdalla M.; Abbas, Ikhlass M.
Journal fuer Praktische Chemie (Leipzig), 1989 , vol. 331, # 1 p. 31 - 36
反应条件
silica gel; diethylamine 0.25 h; neat (no solvent);
参考文献
Bakavoli, Mehdi; Rahimizadeh, Mohammad; Gordi, Zinat
Journal of Chemical Research, 2008 , # 10 p. 564 - 565
反应条件
1: 92 percent / NaOH / ethanol; H2O 2: 72 percent / conc. hydrochloric acid / acetic acid / 1 h / Heating View Scheme
参考文献
Maeda, Yutaka; Nakano, Masato; Sato, Hideyuki; Miyazaki, Yasushi; Schweiker, Stephanie L.; Smith, Jeffery L.; Truesdale, Anne T.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 15 p. 3907 - 3911
反应条件
12 h; Heating / reflux;
参考文献
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; JEIL PHARMACEUTICAL CO., LTD.
Patent: WO2005/92896 A1, 2005 ;
Location in patent: Page/Page column 37-38 ;
WO 2005/092896 A1