2,3-二氢-1H-茚-1-基乙腈合成路线 （共 9 条）
反应条件
phosphorus pentoxide
Heating;
参考文献
Roy, A.; Gupta, J. K.; Lahiri, S.C.
Journal of the Indian Chemical Society, 1983 , vol. 60, p. 377 - 380
反应条件
1: 98 percent / SOCl2, NH3
2: 88 percent / P2O5 / Heating
View Scheme
参考文献
Roy, A.; Gupta, J. K.; Lahiri, S.C.
Journal of the Indian Chemical Society, 1983 , vol. 60, p. 377 - 380
反应条件
hydrogen; sodium hydride; palladium on activated charcoal
Multistep reaction;
参考文献
Ellingboe; Alessi; Dolak; Nguyen; Tomer; Guzzo; Bagli; McCaleb
Journal of Medicinal Chemistry, 1992 , vol. 35, # 7 p. 1176 - 1183
反应条件
1: aq. KOH / ethanol
2: SOCl2 / benzene
3: aq. NH3
4: SOCl2 / benzene
View Scheme
参考文献
Data; Taylor; Forcione
Journal of Pharmaceutical Sciences, 1974 , vol. 63, # 6 p. 848 - 853
反应条件
1: benzene
2: aq. KOH / ethanol
3: SOCl2 / benzene
4: aq. NH3
5: SOCl2 / benzene
View Scheme
参考文献
Data; Taylor; Forcione
Journal of Pharmaceutical Sciences, 1974 , vol. 63, # 6 p. 848 - 853
反应条件
1: aq. NH3
2: SOCl2 / benzene
View Scheme
参考文献
Data; Taylor; Forcione
Journal of Pharmaceutical Sciences, 1974 , vol. 63, # 6 p. 848 - 853
反应条件
1: ammonium chloride, zinc / methanol / 40 h / Heating
2: 77 percent / 1.1 M tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 20 °C
3: 89 percent / AIBN, tributylstannane / cyclohexane / 4 h / Heating
View Scheme
参考文献
Boivin, Jean; Fouquet, Eric; Zard, Samir Z.
Tetrahedron, 1994 , vol. 50, # 6 p. 1757 - 1768
反应条件
1: zinc / diethyl ether / 1.25 h / 15 °C / sonication
2: ammonium chloride, zinc / methanol / 40 h / Heating
3: 77 percent / 1.1 M tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 20 °C
4: 89 percent / AIBN, tributylstannane / cyclohexane / 4 h / Heating
View Scheme
参考文献
Boivin, Jean; Fouquet, Eric; Zard, Samir Z.
Tetrahedron, 1994 , vol. 50, # 6 p. 1757 - 1768
反应条件
sodium azide; ammonium chloride in N,N-dimethyl-formamide
T=120 - 150°C;
参考文献
Roy, A.; Gupta, J. K.; Lahiri, S.C.
Journal of the Indian Chemical Society, 1983 , vol. 60, p. 377 - 380
