1: (R)-phenylethylene oxide; sec.-butyllithium in tetrahydrofuran; hexane; cyclohexane T=-58°C; 0.00330556 h; 2: methyl iodide in tetrahydrofuran; hexane; cyclohexane T=-58°C; 0.000555556 h;

sodium hydroxide; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran 13 h; Heating;

1: (R)-phenylethylene oxide With sec.-butyllithium in tetrahydrofuran; hexane; cyclohexane T=-38°C; 0.00661111 h; flow microreactor; 2: methyl iodide in tetrahydrofuran; hexane; cyclohexane T=-38°C; 0.000555556 h; flow microreactor;

1: (R)-phenylethylene oxide With sec.-butyllithium in tetrahydrofuran; hexane; cyclohexane T=-38°C; 0.000861111 h; flow microreactor; 2: methyl iodide in tetrahydrofuran; hexane; cyclohexane T=-38°C; 0.000555556 h; flow microreactor;

in tetrahydrofuran -70 deg C, 20 min; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

Yield given. Multistep reaction;