264208-86-8合成路线

123855-51-6N-Boc-4-哌啶甲醇+193002-25-47-羟基-6-甲氧基-3-((特戊酰氧基)甲基)-3,4-二氢喹唑啉-4-酮→264208-86-8

参考文献

AstraZeneca AB
Patent: EP1244647 B1, 2006 ;
Location in patent: Page/Page column 22-23 ;
EP 1244647 B1

193002-25-47-羟基-6-甲氧基-3-((特戊酰氧基)甲基)-3,4-二氢喹唑啉-4-酮+166815-96-9N-Boc-4-(4-甲苯磺酰氧基甲基)哌啶→264208-86-8

参考文献

AstraZeneca AB
Patent: EP1119567 B1, 2005 ;
Location in patent: Page/Page column 45 ;

264208-86-8→264208-72-24-氯-6-甲氧基-7-[(1-甲基-4-哌啶基)甲氧基]-喹唑烷

参考文献

Hennequin, Laurent F.; Stokes, Elaine S. E.; Thomas, Andrew P.; Johnstone, Craig; Ple, Patrick A.; Ogilvie, Donald J.; Dukes, Michael; Wedge, Stephen R.; Kendrew, Jane; Curwen, Jon O.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 6 p. 1300 - 1312

264208-86-8→264208-69-76-甲氧基-7-((1-甲基哌啶-4-基)甲氧基)喹唑啉-4(3h)-酮

参考文献

Hennequin, Laurent F.; Stokes, Elaine S. E.; Thomas, Andrew P.; Johnstone, Craig; Ple, Patrick A.; Ogilvie, Donald J.; Dukes, Michael; Wedge, Stephen R.; Kendrew, Jane; Curwen, Jon O.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 6 p. 1300 - 1312