反应条件
1: sodium methylate / ethanol / 40 h / |Reflux 2: lithium hydroxide hydrate; water / methanol / 16 h / 70 °C 3: diphenyl phosphoryl azide; triethylamine / 48 h / 85 °C 4: dichloromethane / 20 °C 5: triethylamine / dichloromethane / 0.5 h / 20 °C / |Resolution of racemate 6: water; hydrogenchloride / ethanol / 72 h / |Reflux View Scheme
参考文献
Li, Huiying; Xue, Fengtian; Kraus, James M.; Ji, Haitao; Labby, Kristin Jansen; Mataka, Jan; Delker, Silvia L.; Martasek, Pavel; Roman, Linda J.; Poulos, Thomas L.; Silverman, Richard B.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 5 p. 1333 - 1343
