4-溴-1,2-亚甲二氧基苯合成路线 （共 128 条）
反应条件
1: 1. Mg / 1..I2 / 1. THF, 2. reflux, 30min 2: 75 percent / pyridine / acetone / 1.5 h / 0 °C View Scheme
参考文献
Azafonov, N. E.; Sedishev, I. P.; Zhulin, V. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 4.1 p. 738 - 741
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 4 p. 829 - 832
反应条件
potassium carbonate; copper(l) iodide; bis(η3-allyl-μ-chloropalladium(II)); dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine in tetrahydrofuran; N,N-dimethyl-formamide
T=75°C; 27 h; Product distribution / selectivity;
参考文献
Nakao, Yoshiaki; Hiyama, Tamejiro
Patent: US2009/69577 A1, 2009 ;
Location in patent: Page/Page column 21; 23-24 ;
反应条件
triethylamine; palladium diacetate in various solvent(s)
T=80°C; Heck reaction; 12 h;
参考文献
Chandrasekhar; Narsihmulu; Shameem Sultana; Ramakrishna Reddy
Organic Letters, 2002 , vol. 4, # 25 p. 4399 - 4401
反应条件
palladium diacetate; i-Pr2NPPh2; potassium carbonate in tetrahydrofuran
Suzuki-Miyamura cross-coupling reaction; 12 h; Heating;
参考文献
Cheng, Jiang; Wang, Feng; Xu, Jian-Hua; Pan, Yi; Zhang, Zhaoguo
Tetrahedron Letters, 2003 , vol. 44, # 37 p. 7095 - 7098
反应条件
tetrabutyl ammonium fluoride; palladium dichloride; tri-cyclo-hexyl-phosphine in water; dimethyl sulfoxide
T=80°C; 2 h;
参考文献
Sahoo, Akhila K.; Oda, Takuro; Nakao, Yoshiaki; Hiyama, Tamejiro
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1715 - 1727
反应条件
potassium carbonate; copper(l) iodide; bis(η3-allyl-μ-chloropalladium(II)); dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine in tetrahydrofuran; N,N-dimethyl-formamide
T=75°C; 27 h; Product distribution / selectivity;
参考文献
Nakao, Yoshiaki; Hiyama, Tamejiro
Patent: US2009/69577 A1, 2009 ;
Location in patent: Page/Page column 21; 23-24 ;
反应条件
1: 1,2-methylenedioxy-4-bromobenzene With tert.-butyl lithium in pentane
T=-78 - 20°C; 0.5 h;
2: o-di-fluorobenzene in tetrahydrofuran; ethylene glycol dimethyl ether; pentane
T=70°C; 12 h;
参考文献
Becht, Jean-Michel; Gissot, Arnaud; Wagner, Alain; Mioskowski, Charles
Chemistry - A European Journal, 2003 , vol. 9, # 14 p. 3209 - 3215
反应条件
bis(carbene)-derived nickel(II)-pincer complex in tetrahydrofuran
T=20°C; Grignard coupling reaction; 48 h;
参考文献
Inamoto, Kiyofumi; Kuroda, Jun-Ichi; Sakamoto, Takao; Hiroya, Kou
Synthesis, 2007 , # 18 p. 2853 - 2861
反应条件
Pd/Fe3O4; cesium fluoride in 1,4-dioxane
T=100°C; Stille Cross Coupling; 18 h;
参考文献
Prasad, Aviraboina Siva; Satyanarayana, Bollikonda
Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 8 p. 2789 - 2792
反应条件
2 Pd/C; sodium hydroxide in water
T=100°C; Hiyama Coupling; 4 h;
参考文献
Mittapelly, Nagaraju; Mukkanti, Khagga; Reguri, Buchi Reddy
Asian Journal of Chemistry, 2014 , vol. 26, # 4 p. 1015 - 1018
