4-溴-1,2-亚甲二氧基苯合成路线 （共 128 条）
反应条件
1: 1,2-methylenedioxy-4-bromobenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Inert atmosphere; 2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; hexane T=-78°C; Inert atmosphere;
参考文献
Ebner, David C.; Bagdanoff, Jeffrey T.; Ferreira, Eric M.; McFadden, Ryan M.; Caspi, Daniel D.; Trend, Raissa M.; Stoltz, Brian M.
Chemistry - A European Journal, 2009 , vol. 15, # 47 p. 12978 - 12992
反应条件
1.1: n-BuLi / hexane; tetrahydrofuran / 0.17 h / -78 °C 1.2: hexane; tetrahydrofuran / 2.5 h / -78 - 20 °C 2.1: hexane; tetrahydrofuran / 2 h / 20 °C 2.2: glacial acetic acid / hexane; tetrahydrofuran / 18 h / 20 °C View Scheme
参考文献
Takagi, Jun; Yamakawa, Tetsu
Tetrahedron Letters, 2013 , vol. 54, # 2 p. 166 - 169
反应条件
diethylzinc; palladium diacetate; di-tert-butyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine in hexanes; N,N-dimethyl acetamide T=40°C; P=7600.51 Torr; Automated synthesizer;
参考文献
Correa, Arkaitz; Martin, Ruben
Journal of the American Chemical Society, 2009 , vol. 131, # 44 p. 15974 - 15975
反应条件
n-butyllithium; diethyl ether T=-35°C; Behandeln des Reaktionsgemisches mit festem Kohlendioxid;
参考文献
Gensler; Stouffer
Journal of Organic Chemistry, 1958 , vol. 23, p. 908
反应条件
T=-35°C; Behandeln des Reaktionsgemisches mit festem Kohlendioxid;
参考文献
Gensler; Stouffer
Journal of Organic Chemistry, 1958 , vol. 23, p. 908
反应条件
1: 1,2-methylenedioxy-4-bromobenzene With magnesium in tetrahydrofuran 2: allyl bromide With ammonium chloride in water
参考文献
Jiang, Huanfeng; Yang, Wanfei; Chen, Huoji; Li, Jianxiao; Wu, Wanqing
Chemical Communications, 2014 , vol. 50, # 54 p. 7202 - 7204
反应条件
1: in tetrahydrofuran T=-75°C; 2.5 h; 2: With tri-isopropoxy-borane in tetrahydrofuran T=-75 - 25°C; 13 h; 3: With hydrogenchloride; water in tetrahydrofuran pH=~ 5 - ~ 6;
参考文献
REDDY US THERAPEUTICS, INC.; KALLEDA, Srinivas; PADAKANTI, Srinivas; KUMAR SWAMY, Nalivela; YELESWARAPU, Koteswar, Rao; ALEXANDER, Christopher, W.; KHANNA, Ish, Kumar; IQBAL, Javed; PILLARISETTI, Sivaram; PAL, Manojit; BARANGE, Deepak
Patent: WO2006/34473 A2, 2006 ;
Location in patent: Page/Page column 237-238 ;
反应条件
n-butyllithium in tetrahydrofuran; ethyl acetate
参考文献
US2014/128392 A1, ;
Page/Page column ;
反应条件
hydrogenchloride; magnesium in tetrahydrofuran treatment of Grignard reagent (prepd. from bromoderivative) with B(OBu)3 (-78°C), hydrolysis of ester with aq. HCl;
参考文献
Banwell; Cowden; Mackay
Journal of the Chemical Society - Series Chemical Communications, 1994 , # 1 p. 61 - 62
反应条件
1: 1,2-methylenedioxy-4-bromobenzene With magnesium in tetrahydrofuran 19 h; Heatingp; 2: boric acid trimethyl ester in tetrahydrofuran T=-78°C; 3 h; 3: With hydrogenchloride in tetrahydrofuran T=20°C; 15 h;
参考文献
Hiroya, Kou; Itoh, Shin; Sakamoto, Takao
Journal of Organic Chemistry, 2004 , vol. 69, # 4 p. 1126 - 1136
