1,2-苯并异噻唑-3-酮合成路线 （共 63 条）
反应条件
potassium carbonate in tetrahydrofuran
T=20 - 25°C; 2 h;
参考文献
Liu, Dazhi; Tian, Zhen; Yan, Zhihui; Wu, Lixin; Ma, Yan; Wang, Quan; Liu, Wei; Zhou, Honggang; Yang, Cheng
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 11 p. 2960 - 2967
参考文献
McClelland; D'Silva
Journal of the Chemical Society, 1931 , p. 2972,2975
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McClelland
Journal of the Chemical Society, 1929 , p. 1591
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D'Silva; McClelland
Journal of the Chemical Society, 1932 , p. 2883,2886
反应条件
in chloroform
T=60°C; 5 h;
参考文献
Xu, Fengling; Lin, Qiang; Hou, Baorong
Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 2 p. 320 - 323
参考文献
Bayer Aktiengesellschaft
Patent: US4599427 A1, 1986 ;
反应条件
1: 77 percent / POCl3 / 3.5 h / 20 - 120 °C
2: 68 percent / 24 h / 125 °C
3: 91 percent / K2CO3, 18-crown-6 / aq. ethanol / 24 h / Heating
4: 88 percent / K2CO3, 18-crown-6 / toluene / 22 h / Heating
View Scheme
参考文献
Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
反应条件
sodium hydroxide in water
6 h; Heating;
参考文献
Slawik, Tomasz
Pharmazie, 1991 , vol. 46, # 11 p. 777 - 780
反应条件
1: POCl3 / pyridine / 120 - 140 °C
2: Na
View Scheme
参考文献
Vitali,T. et al.
Farmaco, Edizione Scientifica, 1968 , vol. 23, p. 1081 - 1096
反应条件
1: POCl3 / pyridine / 120 - 140 °C
2: Na
View Scheme
参考文献
Vitali,T. et al.
Farmaco, Edizione Scientifica, 1968 , vol. 23, p. 1081 - 1096
反应条件
1: 78 percent / triethylamine / benzene / 24 h / Ambient temperature
2: 34 percent / 50percent NH2-NH2*H2O / ethanol / Heating
View Scheme
参考文献
Slawik, Tomasz
Pharmazie, 1991 , vol. 46, # 11 p. 777 - 780
反应条件
potassium carbonate in tetrahydrofuran
T=20 - 25°C; 2 h;
参考文献
Liu, Dazhi; Tian, Zhen; Yan, Zhihui; Wu, Lixin; Ma, Yan; Wang, Quan; Liu, Wei; Zhou, Honggang; Yang, Cheng
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 11 p. 2960 - 2967
