2,4,6-三甲基苯溴化镁合成路线 （共 186 条）
反应条件
magnesium in tetrahydrofuran T=80°C; 0.333333 h; microwave irradiation;
参考文献
Zhao, Fei; Yu, Da-Gang; Zhu, Ru-Yi; Xi, Zhenfeng; Shi, Zhang-Jie
Chemistry Letters, 2011 , vol. 40, # 9 p. 1001 - 1003
反应条件
in tetrahydrofuran under N2, 24 h stirring at reflux, cooled to 25°C,quenched with MeOH, pptn. by addn. of heptane; filtered, freed of volatike solvent, dark residue redigested with warm heptane, filtered, solvent removal, recrystn. from acetonitrile and charcoal, repeated recrystn. from CH3CN-CH2Cl2, elem. anal.;
参考文献
Eisch, John J.; Shafii, Babak; Odom, Jerome D.; Rheingold, Arnold L.
Journal of the American Chemical Society, 1990 , vol. 112, # 5 p. 1847 - 1853
反应条件
1: tetrahydrofuran 2: tetrahydrofuran View Scheme
参考文献
Eisch, John J.; Shafii, Babak; Odom, Jerome D.; Rheingold, Arnold L.
Journal of the American Chemical Society, 1990 , vol. 112, # 5 p. 1847 - 1853
反应条件
in tetrahydrofuran 3 h; Ambient temperature;
参考文献
Du, Chi-Jen Frank; Hart, Harold; Ng, Kwok-Keung Daniel
Journal of Organic Chemistry, 1986 , vol. 51, # 16 p. 3162 - 3165
反应条件
in tetrahydrofuran 1.) RT, 13 h, 2.) reflux, 3 h;
参考文献
Saednya, Akbar; Hart, Harold
Synthesis, 1996 , # 12 p. 1455 - 1458
反应条件
1: 2,4-dichloro-benzene With n-butyllithium in tetrahydrofuran T=-80°C; 2 h; Inert atmosphere; 2: 2,4,6-trimethylphenylmagnesium bromide in tetrahydrofuran T=-80°C; 14 h; Inert atmosphereReflux;
参考文献
Reiss, Fabian; Schulz, Axel; Villinger, Alexander; Weding, Nico
Dalton Transactions, 2010 , vol. 39, # 41 p. 9962 - 9972
参考文献
Smith; MacDougall
Journal of the American Chemical Society, 1929 , vol. 51, p. 3002
Full Text Show Details
Smith
Organic Syntheses, 11 <New York 1931>, S. 66
参考文献
Lapkin; Ponomarewa; Pinegina
Zhurnal Obshchei Khimii, 1952 , vol. 22, p. 1365
Chem.Abstr., 1953 , p. 4861
反应条件
2: (saponification) View Scheme
参考文献
Lapkin,I.I.; Karavanov,N.A.
Zhurnal Organicheskoi Khimii, 1966 , vol. 2, p. 17 - 19,14 - 15
参考文献
Baciocchi,E. et al.
Journal of Organic Chemistry, 1977 , vol. 42, p. 3682 - 3686
