alpha-溴-4-甲氧基苯乙酮合成路线 （共 261 条）
反应条件
1: N,N-dimethylaniline / 170 °C
2: BBr3 / CH2Cl2 / -60 - 20 °C
View Scheme
参考文献
Angerer, Erwin von; Prekajac, Jelica; Strohmeier, Josef
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1439 - 1447
反应条件
N,N-dimethyl-aniline in xylene
T=150°C; 15 h;
参考文献
Mahboobi, Siavosh; Eichhorn, Emerich; Winkler, Matthias; Sellmer, Andreas; Moellmann, Ute
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 3 p. 633 - 656
反应条件
N,N-dimethyl-aniline
T=170°C;
参考文献
BAYLOR UNIVERSITY
Patent: WO2004/99139 A1, 2004 ;
Location in patent: Page 26-27 ;
反应条件
N,N-dimethyl-aniline
T=150°C; Bischler-Moehlau reaction; P=1034.32 Torr; 0.166667 h; Microwave irradiationNeat (no solvent); regioselective reaction;
参考文献
Vara, Yosu; Aldaba, Eneko; Arrieta, Ana; Pizarro, Jose L.; Arriortua, Maria I.; Cossio, Fernando P.
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 10 p. 1763 - 1772
参考文献
Koh, Han Joong; Han, Kwang Lae; Lee, Hai Whang; Lee, Ikchoon
Journal of Organic Chemistry, 2000 , vol. 65, # 15 p. 4706 - 4711
参考文献
Bahner et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 3499
参考文献
Bahner et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 4455
反应条件
1: 90 percent / DIEA / dimethylformamide / 4 h / 20 °C
2: 87 percent / pyridine / ethanol / 2 h / Heating
3: 80 percent / BH3*THF / tetrahydrofuran / 3.5 h / Heating
4: 75 percent / sodium cyanoborohydride; HCl / methanol / 24 h / 20 °C
View Scheme
参考文献
Tchertchian, Sylvie; Hartley, Oliver; Botti, Paolo
Journal of Organic Chemistry, 2004 , vol. 69, # 26 p. 9208 - 9214
参考文献
Maeda,M.; Kojima,M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1977 , p. 239 - 247
反应条件
1: 78 percent / NaBH4 / ethanol / 0 - 20 °C
View Scheme
参考文献
Kamila, Sukanta; Zhu, Dunming; Biehl, Edward R.; Hua, Ling
Organic Letters, 2006 , vol. 8, # 20 p. 4429 - 4431
