3-乙基-1H-吡唑-5-羧酸乙酯合成路线 （共 9 条）
反应条件
hydrazine hydrate in ethanol; acetic acid; butanone
参考文献
Pfizer Inc.
Patent: US6251904 B1, 2001 ;
反应条件
1: oxalic acid diethyl ester With sodium ethanolate in ethanol T=0°C; 0.25 h; 2: With butanone T=20 - 40°C; 24 h; 3: acetic acid With hydrazine hydrate more than 3 stages;
参考文献
Pfizer Inc.
Patent: US6350751 B1, 2002 ;
Location in patent: Page column 9 ;
反应条件
1: oxalic acid diethyl ester With ethanol; sodium ethanolate T=3°C; Cooling with ice/industrial methylated spiritCooling with ice; 2: butanone in ethanol T=20 - 40°C; Cooling with ice;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/147188 A1, 2009 ;
Location in patent: Page/Page column 110-111 ;
WO 2009/147188 A1
反应条件
1: oxalic acid diethyl ester; butanone With sodium ethanolate in ethanol T=0 - 40°C; 24 h; 2: hydrazine With acetic acid in ethanol; water T=0 - 20°C; 18.5 h;
参考文献
Pfizer Inc.
Patent: US6723719 B1, 2004 ;
Location in patent: Page column 44 ;
反应条件
hydrazine hydrate; acetic acid T=80°C; 5 h;
参考文献
Song, Hongjian; Liu, Yuxiu; Xiong, Lixia; Li, Yongqiang; Yang, Na; Wang, Qingmin
Journal of Agricultural and Food Chemistry, 2012 , vol. 60, # 6 p. 1470 - 1479
反应条件
Alkaline hydrolysis;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 17 p. 4914 - 4919
反应条件
sodium carbonate in dichloromethane T=40 - 80°C; 5 h;
参考文献
Song, Hongjian; Liu, Yuxiu; Xiong, Lixia; Li, Yongqiang; Yang, Na; Wang, Qingmin
Journal of Agricultural and Food Chemistry, 2012 , vol. 60, # 6 p. 1470 - 1479
反应条件
1.1: N-bromosuccinmide / chloroform / 12 h / 20 °C 2.1: potassium carbonate / acetone / 10 h / 50 °C 3.1: water; sodium hydroxide / methanol / 4 h / Reflux 3.2: pH 2 / Acidic conditions View Scheme
参考文献
Zhang, Da Qiang; Xu, Gao Fei; Fan, Zhi Jin; Wang, Dao Quan; Yang, Xin Ling; Yuan, De Kai
Chinese Chemical Letters, 2012 , vol. 23, # 6 p. 669 - 672
反应条件
1.1: sodium carbonate / dichloromethane / 5 h / 40 - 80 °C 2.1: sodium hydroxide / ethanol / Reflux 2.2: pH 2 View Scheme
参考文献
Song, Hongjian; Liu, Yuxiu; Xiong, Lixia; Li, Yongqiang; Yang, Na; Wang, Qingmin
Journal of Agricultural and Food Chemistry, 2012 , vol. 60, # 6 p. 1470 - 1479
