(S)-(-)- α-甲基苄胺合成路线 （共 369 条）
反应条件
1: With [Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; potassium tert-butylate; 2-amino-2-methyl-propan-1-ol in isopropyl alcohol T=50°C; 2 h; Molecular sieve; 2: With hydrogenchloride in methanol optical yield given as percent eediastereoselective reaction;
参考文献
Guijarro, David; Pablo, Oscar; Yus, Miguel
Tetrahedron Letters, 2011 , vol. 52, # 7 p. 789 - 791
反应条件
borane-THF; 1-[([1,3,2]dioxaborolan-2-yloxy)-diphenyl-methyl]-2-methylpropylamine in 1,4-dioxane T=0°C; Product distribution / selectivity;
参考文献
OFFICE OF INTELLECTUAL PROPERTY AND TECHNOLOGY
Patent: WO2008/27740 A2, 2008 ;
Location in patent: Page/Page column 11 ;
反应条件
borane-THF; 1-[([1,3,2]dioxaborolan-2-yloxy)-diphenyl-methyl]-2-methylpropylamine in 1,4-dioxane T=0°C; Product distribution / selectivity;
参考文献
OFFICE OF INTELLECTUAL PROPERTY AND TECHNOLOGY
Patent: WO2008/27740 A2, 2008 ;
Location in patent: Page/Page column 11 ;
反应条件
borane-THF; 1-[([1,3,2]dioxaborolan-2-yloxy)-diphenyl-methyl]-2-methylpropylamine in 1,4-dioxane T=0°C; Product distribution / selectivity;
参考文献
OFFICE OF INTELLECTUAL PROPERTY AND TECHNOLOGY
Patent: WO2008/27740 A2, 2008 ;
Location in patent: Page/Page column 11 ;
反应条件
borane-THF; 1-[([1,3,2]dioxaborolan-2-yloxy)-diphenyl-methyl]-2-methylpropylamine in 1,4-dioxane T=0°C; Product distribution / selectivity;
参考文献
OFFICE OF INTELLECTUAL PROPERTY AND TECHNOLOGY
Patent: WO2008/27740 A2, 2008 ;
Location in patent: Page/Page column 11 ;
反应条件
formate dehydrogenase; Arthrobacter citreus S9 ω-transaminase; ATA-113 ω-transaminase; sodium formate; isopropylamine; Reduced nicotinamide-adenine dinucleotide; yeast alcohol dehydrogenase pH=7; aq. phosphate bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
Cassimjee, Karim Engelmark; Branneby, Cecilia; Abedi, Vahak; Wells, Andrew; Berglund, Per
Chemical Communications, 2010 , vol. 46, # 30 p. 5569 - 5571
反应条件
1: With [((R)-tol-binap)RuCl2(DMF)x]; ammonia; ammonium formate in methanol T=85°C; Leuckart-Wallach reaction; 20 h; 2: With hydrogenchloride in ethanol 1 h; Heating; Title compound not separated from byproducts;
参考文献
Nieto, Sonia; Dragna, Justin M.; Anslyn, Eric V.
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 227 - 232
反应条件
ammonia; lithium in tetrahydrofuran T=-78°C; 0.25 h;
参考文献
Nishimura, Takahiro; Yasuhara, Yuichi; Hayashi, Tamio
Organic Letters, 2006 , vol. 8, # 5 p. 979 - 981
反应条件
sodium tetrahydroborate; (S)-valinol; zirconium tetrachloride 1) THF, r.t., 2) THF, r.t.; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Itsuno, Shinichi; Sakurai, Yoshiki; Shimizu, Koji; Ito, Koichi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 7 p. 1859 - 1863
反应条件
1: With borane; L-ERYTHRO-(1R,2S)-2-AMINO-1-PHENYLPROPAN-1-OL in tetrahydrofuran T=20°C; 20 h; 2: With hydrogenchloride in tetrahydrofuran T=20°C; 30 h; Further stages.;
参考文献
Laczkowski, Krzysztof Z.; Pakulski, Marcin M.; Krzeminski, Marek P.; Jaisankar, Parasuraman; Zaidlewicz, Marek
Tetrahedron Asymmetry, 2008 , vol. 19, # 7 p. 788 - 795
