6-甲氧基吡啶-2-羧酸甲酯合成路线 (共 8 条)
反应条件
silver carbonate in chloroform T=60°C; 26 h; Time;
参考文献
HANMI PHARM. CO., LTD.; BANG, Keuk Chan; PARK, Chang Hee; CHOI, Jae Yul; KIM, Seo Hee; HAM, Young Jin
Patent: WO2014/3483 A1, 2014 ;
Location in patent: Page/Page column 34 ;
反应条件
thionyl chloride T=70°C; 16 h;
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;
Location in patent: Paragraph 0525; 0526 ;
反应条件
1: N,N-dimethyl-formamide / 16 h / 20 - 100 °C 2: thionyl chloride / 16 h / 70 °C View Scheme
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;
反应条件
sulfuric acid 0.166667 h; Irradiation; Product distributionMechanism;
参考文献
Sugiyama, Toru; Tobita, Estuo; Takagi, Kyoko; Sato, Michitsugu; Kumagai, Yasuyuki; et al.
Chemistry Letters, 1980 , p. 131 - 134
反应条件
2-pyridine carbonitrile; sulfuric acid T=25.5°C; 0.0333333 h; Irradiationother substituted pyridines as promotors; Mechanism;
参考文献
Sugimori; Ogishima; Miyazawa; Hasegawa; Suzuki
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 6 p. 1817 - 1821
参考文献
Senomyx, Inc.
Patent: US2009/274632 A1, 2009 ;
反应条件
1.1: lithium aluminium tetrahydride / diethyl ether / 4 h 1.2: Molecular sieve 2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h View Scheme
参考文献
ARRAY BIOPHARMA INC.; BOYS, Mark Laurence; BRADLEY, Michael; DELISLE, Robert Kirk; HENNINGS, D. David; KENNEDY, April L.; MARMSATER, Fredrik P.; MEDINA, Matthew; MUNSON, Mark C.; RAST, Bryson; RIZZI, James P.; RODRIGUEZ, Martha E.; TOPALOV, George T.; ZHAO, Qian
Patent: WO2011/79076 A1, 2011 ;
反应条件
1: sodium tetrahydroborate / ethanol / 3 h / 0 - 20 °C
2: thionyl chloride / monofluorodichloromethane / 2 h / 0 - 50 °C / Inert atmosphere
View Scheme
参考文献
HANMI PHARM. CO., LTD.; BANG, Keuk Chan; PARK, Chang Hee; CHOI, Jae Yul; KIM, Seo Hee; HAM, Young Jin
Patent: WO2014/3483 A1, 2014 ;