(R)-3-氨基-3-(3-氯苯基)-丙酸合成路线 （共 6 条）
反应条件
CAL-B (lipase B from Candida antarctica); water in isopropyl alcohol T=60°C; 11 h;
参考文献
Forro, Eniko; Paal, Tihamer; Tasnadi, Gabor; Fueloep, Ferenc
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 7-8 p. 917 - 923
反应条件
penicillin acylase (E. coli); sodium hydrogencarbonate Hydrolysis; Enzymatic reaction;
参考文献
Renault, Olivier; Guillon, Jean; Dallemagne, Patrick; Rault, Sylvain
Tetrahedron Letters, 2000 , vol. 41, # 5 p. 681 - 683
反应条件
1.1: toluene / 8 h / 20 °C 1.2: 67 percent / Na2SO3; Na2CO3 / toluene; H2O 2.1: 46 percent / CAL-B (lipase B from Candida antarctica); water / propan-2-ol / 11 h / 60 °C View Scheme
参考文献
Forro, Eniko; Paal, Tihamer; Tasnadi, Gabor; Fueloep, Ferenc
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 7-8 p. 917 - 923
反应条件
1: 75 percent / Et3N / acetone; H2O 2: 70 percent / penicillin acylase (E. coli); aq. NaHCO3 / Enzymatic reaction View Scheme
参考文献
Li, Dengchao; Ji, Lilian; Wang, Xinfeng; Wei, Dongzhi
Preparative Biochemistry and Biotechnology, 2013 , vol. 43, # 2 p. 207 - 216
反应条件
1: ammonium acetate / ethanol / 6 h / |Reflux 2: recombinant Alcaligenes faecalis penicillin G acylase / aq. phosphate buffer / 1.5 h / 25 °C / pH 11 / |Enzymatic reaction 3: recombinant Alcaligenes faecalis penicillin G acylase / pH 7.5 View Scheme
参考文献
Li, Dengchao; Ji, Lilian; Wang, Xinfeng; Wei, Dongzhi
Preparative Biochemistry and Biotechnology, 2013 , vol. 43, # 2 p. 207 - 216
反应条件
carbon dioxide; Taxus chinensis phenylalanine aminomutase; ammonia in water pH=10; Enzymatic reaction; Kinetics; optical yield given as percent eeenantioselective reaction;
参考文献
Szymanski, Wiktor; Wu, Bian; Weiner, Barbara; De Wildeman, Stefaan; Feringa, Ben L.; Janssen, Dick B.
Journal of Organic Chemistry, 2009 , vol. 74, # 23 p. 9152 - 9157
