1-甲基-2-苯基苯并咪唑合成路线 （共 38 条）
反应条件
1: pyridine
2: hydrogen / 5percent Pd-C / ethanol / Ambient temperature
3: 6M hydrochloric acid / 0.5 h / Heating
4: 45 percent / various solvent(s) / 4 h / Heating
View Scheme
参考文献
King, Frank D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 3381 - 3386
反应条件
1: pyridine
2: hydrogen / 5percent Pd-C / ethanol / Ambient temperature
3: 6M hydrochloric acid / 0.5 h / Heating
4: 45 percent / various solvent(s) / 4 h / Heating
View Scheme
参考文献
King, Frank D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 3381 - 3386
反应条件
1: hydrogen / 5percent Pd-C / ethanol / Ambient temperature
2: 6M hydrochloric acid / 0.5 h / Heating
3: 45 percent / various solvent(s) / 4 h / Heating
View Scheme
参考文献
King, Frank D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 3381 - 3386
反应条件
1.1: 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride / dichloromethane / 1 h / 0 - 20 °C / |Inert atmosphere
1.2: 20 °C / |Inert atmosphere
2.1: potassium hydroxide / dimethyl sulfoxide / 16 h / 120 °C / |Inert atmosphere; |Sealed tube
View Scheme
参考文献
Baars, Hannah; Beyer, Astrid; Kohlhepp, Stefanie V.; Bolm, Carsten
Organic Letters, 2014 , vol. 16, # 2 p. 536 - 539
反应条件
1.1: 70 percent / aq. H3PO4 / 6 h / 90 - 200 °C
2.1: NaH / dimethylformamide / 0 - 20 °C
2.2: 60 percent / dimethylformamide / 20 °C
View Scheme
参考文献
Kuebel-Pollak, Anita; Ruettimann, Stephane; Dunn, Nichola; Melich, Xavier; Williams, Alan F.; Bernardinelli, Gerald
Helvetica Chimica Acta, 2006 , vol. 89, # 5 p. 841 - 853
反应条件
1.1: 70 percent / aq. H3PO4 / 6 h / 90 - 200 °C
2.1: NaH / dimethylformamide / 0 - 20 °C
2.2: 60 percent / dimethylformamide / 20 °C
View Scheme
参考文献
Kuebel-Pollak, Anita; Ruettimann, Stephane; Dunn, Nichola; Melich, Xavier; Williams, Alan F.; Bernardinelli, Gerald
Helvetica Chimica Acta, 2006 , vol. 89, # 5 p. 841 - 853
反应条件
T=150 - 650°C; P=0.01 Torr; 3 h; Pyrolysis;
参考文献
Leardini, Rino; McNab, Hamish; Nanni, Daniele; Tenan, Anton G.; Thomson, Andrew
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 3 p. 623 - 630
反应条件
1: 83 percent / 50percent phosphoric acid, NaNO2 / H2O / 0.5 h / -5 - 3 °C
2: 86 percent / benzene / 5 h / Heating
View Scheme
参考文献
Kolodyazhnaya, S. N.; Divaeva, L. N.; Zheltikova, N. N.; Simonov, A. M.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 10 p. 1090 - 1094
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 10 p. 1360 - 1364
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C
2: palladium 10 on activated carbon; hydrogen / methanol / 2 h
3: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / N,N-dimethyl-formamide / 15 h / 110 °C
View Scheme
参考文献
Xue, Ding; Long, Ya-Qiu
Journal of Organic Chemistry, 2014 , vol. 79, # 10 p. 4727 - 4734
反应条件
1: palladium 10 on activated carbon; hydrogen / methanol / 2 h
2: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / N,N-dimethyl-formamide / 15 h / 110 °C
View Scheme
参考文献
Xue, Ding; Long, Ya-Qiu
Journal of Organic Chemistry, 2014 , vol. 79, # 10 p. 4727 - 4734
