N-(氯苯氧基氧化膦基)-L-丙氨酸异丙酯合成路线 (共 2 条)
反应条件
triethylamine in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
WO2012/142085 A1, ;
Page/Page column 74-75 ;
反应条件
Multi-step reaction with 2 steps 1: trichlorophosphate; triethylamine / dichloromethane / 2 h / -78 - 20 °C2: triethylamine / dichloromethane / 2 h / -78 - 20 °C
参考文献
ALIOS BIOPHARMA, INC.; Beigelman, Leonid; Wang, Guangyi; Smith, David Bernard Patent: US2014/179627 A1, 2014 ;