(S)-(+)-alpha-甲氧基苯乙酸合成路线 （共 41 条）
反应条件
1: silver(I) oxide / acetonitrile / 4 h / Heating 2: sodium hydroxide / methanol; H2O / 20 °C 3: H5IO6; RuCl2 / acetonitrile; CCl4; H2O View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 10 p. 1757 - 1762
反应条件
1: Et3N; 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 24 h / 20 °C 2: hydrobromic acid / acetic acid / 1 h / 100 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 3 p. 555 - 563
反应条件
1: 97 percent / AD-mix α / 2-methyl-propan-2-ol; H2O / 2 h / 20 °C 2: 92 percent / DMAP; Et3N / CH2Cl2 / 2 h / 20 °C 3: 87 percent / t-BuOK / acetonitrile / 12 h / 20 °C 4: 100 percent / TBAF / acetonitrile / 4 h / 20 °C 5: 80 percent / TEMPO; NaClO; NaClO2 / acetonitrile; aq. phosphate buffer / 4 h / 55 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 4 p. 503 - 510
反应条件
1: 92 percent / DMAP; Et3N / CH2Cl2 / 2 h / 20 °C 2: 87 percent / t-BuOK / acetonitrile / 12 h / 20 °C 3: 100 percent / TBAF / acetonitrile / 4 h / 20 °C 4: 80 percent / TEMPO; NaClO; NaClO2 / acetonitrile; aq. phosphate buffer / 4 h / 55 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 4 p. 503 - 510
反应条件
1: 87 percent / t-BuOK / acetonitrile / 12 h / 20 °C 2: 100 percent / TBAF / acetonitrile / 4 h / 20 °C 3: 80 percent / TEMPO; NaClO; NaClO2 / acetonitrile; aq. phosphate buffer / 4 h / 55 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 4 p. 503 - 510
反应条件
1: 100 percent / TBAF / acetonitrile / 4 h / 20 °C 2: 80 percent / TEMPO; NaClO; NaClO2 / acetonitrile; aq. phosphate buffer / 4 h / 55 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 4 p. 503 - 510
反应条件
1: 100 percent / 1N aq. HCl / tetrahydrofuran / 4.5 h 2: 91 percent / RuO4*H2O, NaIO4 / CCl4; acetonitrile; H2O / 0.67 h View Scheme
参考文献
Synthetic Communications, , vol. 25, # 18 p. 2837 - 2845
反应条件
sodium carbonate in water; acetonitrile T=25°C; Rate constant;
参考文献
Tetrahedron Letters, , vol. 24, # 49 p. 5541 - 5542
参考文献
Journal of Organic Chemistry, , vol. 62, # 1 p. 62 - 66
反应条件
2: 29 percent / NaBH4 3: 38 percent / BF3*Et2O 4: 54 percent / NaIO4, RuCl3 View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 3, # 11 p. 1381 - 1384
