2-甲基-4-硝基-2H-吲唑合成路线 （共 8 条）
反应条件
1: 4-nitro-1H-indazole With potassium carbonate in tetrahydrofuran T=0°C; 0.25 h; 2: methyl iodide in tetrahydrofuran
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2005/28445 A2, 2005 ;
Location in patent: Page/Page column 35 ;
WO 2005/028445 A2
反应条件
1: 4-nitro-1H-indazole With trifluorormethanesulfonic acid in dichloromethane T=25 - 35°C; Inert atmosphere; 2: methyl 2,2,2-trichloroacetimidate in dichloromethane T=20°C; Inert atmosphere; regioselective reaction;
参考文献
Baddam, Sudhakar Reddy; Uday Kumar; Panasa Reddy; Bandichhor, Rakeshwar
Tetrahedron Letters, 2013 , vol. 54, # 13 p. 1661 - 1663
反应条件
in ethyl acetate T=20°C; 5 h;
参考文献
Cheung, Mui; Boloor, Amogh; Stafford, Jeffrey A.
Journal of Organic Chemistry, 2003 , vol. 68, # 10 p. 4093 - 4095
反应条件
potassium hydroxide; water T=75°C; 0.5 h;
参考文献
Noelting
Chemische Berichte, 1904 , vol. 37, p. 2583
Full Text Show Details
v. Auwers; Frese
Chemische Berichte, 1925 , vol. 58, p. 1373
反应条件
1: 65 percent / NaNO2 / acetic acid; H2O 2: 35 percent / KOH; water / 0.5 h / 75 °C View Scheme
参考文献
Noelting
Chemische Berichte, 1904 , vol. 37, p. 2583
反应条件
1.1: tetrafluoroboric acid; sodium nitrite / water / 3 h / 0 - 20 °C 1.2: 2 h / 20 °C 2.1: potassium carbonate / acetone / |Reflux View Scheme
参考文献
Lohou, Elodie; Sopkova-De Oliveira Santos, Jana; Schumann-Bard, Pascale; Boulouard, Michel; Stiebing, Silvia; Rault, Sylvain; Collot, Valerie
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 17 p. 5296 - 5304
反应条件
hydrogen; palladium on activated charcoal in methanol; dichloromethane T=50°C; P=2250.23 Torr;
参考文献
Miloudi, Abdellah; El Abed, Douniazed; Boyer, Gerard; Galy, Jean-Pierre
Heterocycles, 2006 , vol. 68, # 12 p. 2595 - 2605
反应条件
hydrogenchloride; tin(ll) chloride in methanol Heating;
参考文献
Heterocycles, , vol. 68, # 12 p. 2595 - 2605
