2-氯-5-(三氟甲基)苯甲酸甲酯合成路线 （共 4 条）
反应条件
1: methanol With acetyl chloride T=0°C; 0.166667 h; 2: 2-Chloro-5-(trifluoromethyl)benzoic acid T=0°C; 2.5 h; Heating / reflux;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/136442 A1, 2006 ;
Location in patent: Page/Page column 90 ;
WO 2006/136442 A1
反应条件
in methanol; dichloromethane; N,N-dimethyl-formamide
参考文献
Cell Therapeutics, Inc.
Patent: US2003/153570 A1, 2003 ;
反应条件
hydrogenchloride in water; acetone
参考文献
Merck and Co., Inc.
Patent: US4760086 A1, 1988 ;
反应条件
potassium acetate; tris-(dibenzylideneacetone)dipalladium(0); tri-cyclo-hexyl-phosphine in 1,4-dioxane
T=20 - 80°C; 20 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/136442 A1, 2006 ;
Location in patent: Page/Page column 90-91 ;
WO 2006/136442 A1
