2,2-二氟环丙烷甲酸丁酯合成路线 （共 6 条）
反应条件
NAF in toluene T=105°C;
参考文献
Dolbier Jr., William R.; Tian, Feng; Duan, Jian-Xin; Li, An-Rong; Ait-Mohand, Samia; Bautista, Olivia; Buathong, Saiwan; Baker, J. Marshall; Crawford, Jen; Anselme, Pauline; Cai, Xiao Hong; Modzelewska, Aneta; Koroniak, Henryk; Battiste, Merle A.; Chen, Qing-Yun
Journal of Fluorine Chemistry, 2004 , vol. 125, # 3 p. 459 - 469
反应条件
NAF in toluene T=105°C;
参考文献
Dolbier Jr., William R.; Tian, Feng; Duan, Jian-Xin; Li, An-Rong; Ait-Mohand, Samia; Bautista, Olivia; Buathong, Saiwan; Baker, J. Marshall; Crawford, Jen; Anselme, Pauline; Cai, Xiao Hong; Modzelewska, Aneta; Koroniak, Henryk; Battiste, Merle A.; Chen, Qing-Yun
Journal of Fluorine Chemistry, 2004 , vol. 125, # 3 p. 459 - 469
反应条件
NAF T=105°C; Elimination; Cycloaddition; 2 h;
参考文献
Tian, Feng; Kruger, Virginie; Bautista, Olivia; Duan, Jian-Xin; Li, An-Rong; Dolbier Jr., William R.; Chen, Qing-Yun
Organic Letters, 2000 , vol. 2, # 4 p. 563 - 564
反应条件
1: acrylic acid n-butyl ester With NAF in toluene 1 h; Heating; 2: trimethylsilyl-2,2-difluoro-2-(fluorosulfonyl) acetate in toluene 8 h; Heating;
参考文献
Dolbier Jr., William R.; Gautriaud, Emilie; Cai, Xiaohong
Journal of Fluorine Chemistry, 2005 , vol. 126, # 3 p. 339 - 343
反应条件
chloro-trimethyl-silane; diethylene glycol dimethyl ether; potassium iodide in 1,4-dioxane T=115 - 120°C; 48 h; Inert atmosphere;
参考文献
Eusterwiemann, Steffen; Martinez, Henry; Dolbier, William R.
Journal of Organic Chemistry, 2012 , vol. 77, # 12 p. 5461 - 5464
反应条件
sodium hydroxide Heating;
参考文献
Dolbier Jr., William R.; Gautriaud, Emilie; Cai, Xiaohong
Journal of Fluorine Chemistry, 2005 , vol. 126, # 3 p. 339 - 343
