1,3-苯并噻唑-2-甲腈合成路线 （共 28 条）
反应条件
1: With pyridine; trichlorophosphate T=0 - 20°C; 2.33333 h; Inert atmosphere; 2: With water in ethyl acetate T=0°C;
参考文献
GRYSHUK, Amy L.; Perkins, Julie; LaTour, John V.
Patent: US2011/224442 A1, 2011 ;
Location in patent: Page/Page column 12-13 ;
反应条件
1: potassium cyanide in dimethyl sulfoxide Reflux; 2: 2-chloro-1,3-benzothiazole in dimethyl sulfoxide T=80°C; 17 h;
参考文献
Promega Corporation
Patent: US7692022 B2, 2010 ;
Location in patent: Page/Page column 35-36 ;
US 7692022 B2
反应条件
in tetrahydrofuran T=0 - 25°C;
参考文献
Klement, Ingo; Lennick, Klaus; Tucker, Charles E.; Knochel, Paul
Tetrahedron Letters, 1993 , vol. 34, # 29 p. 4623 - 4626
反应条件
copper (I) cyanide; lithium tert-butylate in 1,4-dioxane; m-xylene T=110°C; 12 h; Inert atmosphere; regioselective reaction;
参考文献
Do, Hien-Quang; Daugulis, Olafs
Organic Letters, 2010 , vol. 12, # 11 p. 2517 - 2519
反应条件
copper (I) cyanide; lithium tert-butylate in 1,4-dioxane; m-xylene T=110°C; 12 h; Inert atmosphere; regioselective reaction;
参考文献
Do, Hien-Quang; Daugulis, Olafs
Organic Letters, 2010 , vol. 12, # 11 p. 2517 - 2519
反应条件
phosphorus pentachloride T=130 - 135°C; 2 h;
参考文献
Uff, Barrie C.; Ho, Yee-Ping; Brown, David S.; Fisher, Ian; Popp, Frank D.; Kant, Joydeep
Journal of Chemical Research, Miniprint, 1989 , # 11 p. 2652 - 2681
反应条件
1: CHCl3 / 16 h / Ambient temperature 2: isopentylnitrite, HCl / dioxane 3: NaN3 / dimethylformamide / 6 h 4: AcOH / 16 h / Ambient temperature View Scheme
参考文献
Baudet,P.; Otten,C.
Helvetica Chimica Acta, 1970 , vol. 53, p. 1683 - 1693
反应条件
in tetrahydrofuran 5 h; Heating;
参考文献
Nagasaki, Izuru; Suzuki, Yumiko; Iwamoto, Ken-Ichi; Higashino, Takeo; Miyashita, Akira
Heterocycles, 1997 , vol. 46, # 1 p. 443 - 450
反应条件
1: CH2Cl2 / 2 h / 20 °C 2: 49 percent / 1-methyl-pyrrolidin-2-one / 0.02 h / 150 °C / microwave irradiation View Scheme
参考文献
Frere, Stephane; Thiery, Valerie; Bailly, Christian; Besson, Thierry
Tetrahedron, 2003 , vol. 59, # 6 p. 773 - 779
反应条件
1: isopentylnitrite, HCl / dioxane 2: NaN3 / dimethylformamide / 6 h 3: AcOH / 16 h / Ambient temperature View Scheme
参考文献
Kristinsson,H.
Synthesis, 1979 , p. 102 - 103
