2-氧代-2H-吡喃-3-甲酸甲酯合成路线 （共 15 条）
反应条件
1.1: N,N-dimethyl-formamide / 7 h / 0 °C / |Inert atmosphere 1.2: 12 h / 20 °C / |Inert atmosphere 2.1: lithium hydroxide hydrate / water; tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Traore, Tenin; Cavagnino, Andrea; Saettel, Nicolas; Radvanyi, Francois; Piguel, Sandrine; Bernard-Pierrot, Isabelle; Stoven, Veronique; Legraverend, Michel
European Journal of Medicinal Chemistry, 2013 , vol. 70, p. 789 - 801
参考文献
Ziegler, Thomas; Layh, Marcus; Effenberger, Franz
Chemische Berichte, 1987 , vol. 120, p. 1347 - 1356
反应条件
in ethylene glycol dimethyl ether
Heatingdifferent 2-pyrones and benzopyrones; Product distribution;
参考文献
Escudero, Sonia; Perez, Dolores; Guitian, Enrique; Castedo, Luis
Tetrahedron Letters, 1997 , vol. 38, # 30 p. 5375 - 5378
反应条件
1.1: N,N-dimethyl-formamide / 3.25 h / 20 °C / Cooling with ice
1.2: 20 °C
2.1: sodium hydroxide; water / methanol / 65 °C
2.2: pH 1
View Scheme
参考文献
ANNJI PHARMACEUTICAL CO., LTD.; Chern, Ji-Wang; Jagtap, Ajit Dhananjay; Wang, Hsiao-Chun; Chen, Grace Shiahuy
Patent: US2013/281451 A1, 2013 ;
反应条件
1: N,N-dimethyl-formamide / 7 h / 0 °C
2: sodium hydroxide / methanol; water / 1 h / pH 1 / |Reflux
View Scheme
参考文献
ZHEJIANG BETA PHARMA INCORPORATION; HU, Shaojing; WANG, Fei; XU, Zhiguo; WANG, Yanping; WANG, Yinxiang
Patent: WO2014/713 A1, 2014 ;
