6,7-二氢恶唑并[5,4-c]吡啶-2,5(4H)-二羧酸 5-叔丁酯 2-甲酯合成路线 （共 8 条）
反应条件
sodium cyanide; manganese(IV) oxide T=20°C; 0.5 h;
参考文献
Komoriya, Satoshi; Kobayashi, Shozo; Osanai, Ken; Yoshino, Toshiharu; Nagata, Tsutomu; Haginoya, Noriyasu; Nakamoto, Yumi; Mochizuki, Akiyoshi; Nagahara, Takayasu; Suzuki, Makoto; Shimada, Takashi; Watanabe, Kengo; Isobe, Yumiko; Furugoori, Taketoshi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 5 p. 1309 - 1330
反应条件
manganese(IV) dioxide in methanol
反应条件
1.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 15 h / 20 °C 1.2: 99 percent / NaOH; H2O2 / tetrahydrofuran; H2O / 6 h / 20 °C 2.1: 95 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 4 h / 20 °C 3.1: hydrazine hydrate / ethanol / 3 h / Heating 4.1: 5.06 g / NaHCO3 / ethanol; CH2Cl2; H2O / 0.5 h / 20 °C 5.1: 78 percent / p-toluenesulfonic acid / toluene / 1 h / Heating 6.1: N-methylmorpholine N-oxide; osmium tetraoxide / tetrahydrofuran; acetone; H2O / 14 h / 20 °C 7.1: 234 mg / sodium periodate / tetrahydrofuran; methanol; H2O / 3 h / 20 °C 8.1: 48 percent / sodium cyanide; manganese(IV) oxide / 0.5 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 5 p. 1309 - 1330
反应条件
1: 95 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 4 h / 20 °C 2: hydrazine hydrate / ethanol / 3 h / Heating 3: 5.06 g / NaHCO3 / ethanol; CH2Cl2; H2O / 0.5 h / 20 °C 4: 78 percent / p-toluenesulfonic acid / toluene / 1 h / Heating 5: N-methylmorpholine N-oxide; osmium tetraoxide / tetrahydrofuran; acetone; H2O / 14 h / 20 °C 6: 234 mg / sodium periodate / tetrahydrofuran; methanol; H2O / 3 h / 20 °C 7: 48 percent / sodium cyanide; manganese(IV) oxide / 0.5 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 5 p. 1309 - 1330
反应条件
1: 78 percent / p-toluenesulfonic acid / toluene / 1 h / Heating 2: N-methylmorpholine N-oxide; osmium tetraoxide / tetrahydrofuran; acetone; H2O / 14 h / 20 °C 3: 234 mg / sodium periodate / tetrahydrofuran; methanol; H2O / 3 h / 20 °C 4: 48 percent / sodium cyanide; manganese(IV) oxide / 0.5 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 5 p. 1309 - 1330
反应条件
1: N-methylmorpholine N-oxide; osmium tetraoxide / tetrahydrofuran; acetone; H2O / 14 h / 20 °C 2: 234 mg / sodium periodate / tetrahydrofuran; methanol; H2O / 3 h / 20 °C 3: 48 percent / sodium cyanide; manganese(IV) oxide / 0.5 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 5 p. 1309 - 1330
反应条件
1: hydrazine hydrate / ethanol / 3 h / Heating 2: 5.06 g / NaHCO3 / ethanol; CH2Cl2; H2O / 0.5 h / 20 °C 3: 78 percent / p-toluenesulfonic acid / toluene / 1 h / Heating 4: N-methylmorpholine N-oxide; osmium tetraoxide / tetrahydrofuran; acetone; H2O / 14 h / 20 °C 5: 234 mg / sodium periodate / tetrahydrofuran; methanol; H2O / 3 h / 20 °C 6: 48 percent / sodium cyanide; manganese(IV) oxide / 0.5 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 5 p. 1309 - 1330
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 20 °C 1.2: 79 percent / tetrahydrofuran; hexane / 2 h / 20 °C 2.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 15 h / 20 °C 2.2: 99 percent / NaOH; H2O2 / tetrahydrofuran; H2O / 6 h / 20 °C 3.1: 95 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 4 h / 20 °C 4.1: hydrazine hydrate / ethanol / 3 h / Heating 5.1: 5.06 g / NaHCO3 / ethanol; CH2Cl2; H2O / 0.5 h / 20 °C 6.1: 78 percent / p-toluenesulfonic acid / toluene / 1 h / Heating 7.1: N-methylmorpholine N-oxide; osmium tetraoxide / tetrahydrofuran; acetone; H2O / 14 h / 20 °C 8.1: 234 mg / sodium periodate / tetrahydrofuran; methanol; H2O / 3 h / 20 °C 9.1: 48 percent / sodium cyanide; manganese(IV) oxide / 0.5 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 5 p. 1309 - 1330
