2-甲基-6-(三丁基锡)吡啶合成路线 （共 12 条）
反应条件
1: tri-n-butyl-tin hydride With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=0°C; 0.5 h; 2: 2-bromo-6-methyl-pyridine in tetrahydrofuran; hexane T=-78°C;
参考文献
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.
Patent: US2010/4443 A1, 2010 ;
Location in patent: Page/Page column 32 ;
反应条件
n-C4H9Li in tetrahydrofuran at -78°C;
参考文献
Kamata, Kouji; Suzuki, Atsuko; Nakai, Yuta; Nakazawa, Hiroshi
Organometallics, 2012 , vol. 31, # 10 p. 3825 - 3828
反应条件
1: 2-bromo-6-methyl-pyridine With n-butyllithium in tetrahydrofuran; hexanes T=-78°C; 1.5 h; 2: tributyltin chloride in tetrahydrofuran; hexanes T=-78 - 20°C; Product distribution / selectivity;
参考文献
TIBOTEC PHARMACEUTICALS LTD.; MEDIVIR AB
Patent: WO2007/14922 A1, 2007 ;
Location in patent: Page/Page column 122 ;
反应条件
in tetrahydrofuran; hexane T=-78 - 20°C; 2 h;
参考文献
US2010/298562 A1, ;
Page/Page column 43-44 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene Stille-type cross-coupling; 48 h; Heating;
参考文献
Heller, Marcel; Schubert, Ulrich S.
Journal of Organic Chemistry, 2002 , vol. 67, # 23 p. 8269 - 8272
反应条件
1: 63 percent / Pd(PPh3)4 / toluene / 72 h / Heating 2: NBS; AIBN / benzene / 3 h / Heating; irradiation View Scheme
参考文献
Bedel, Sebastien; Ulrich, Gilles; Picard, Claude; Tisnes, Pierre
Synthesis, 2002 , # 11 p. 1564 - 1570
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene 96 h; Heating;
参考文献
Sato, Yoshinori; Nakayama, Yuushou; Yasuda, Hajime
Journal of Organometallic Chemistry, 2004 , vol. 689, # 4 p. 744 - 750
反应条件
bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide T=95 - 105°C; Stille Coupling; 24 h; Product distribution / selectivity;
参考文献
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
Patent: US2010/298562 A1, 2010 ;
Location in patent: Page/Page column 40-41 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene
Stille reaction; 48 h; Heating;
参考文献
Bedel, Sebastien; Ulrich, Gilles; Picard, Claude; Tisnes, Pierre
Synthesis, 2002 , # 11 p. 1564 - 1570
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene
72 h; Heating;
参考文献
Galaup, Chantal; Couchet, Jean-Marc; Bedel, Sebastien; Tisnes, Pierre; Picard, Claude
Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2274 - 2284
