6-甲氧基-5-甲基-2(1H)-嘧啶酮合成路线 （共 9 条）
反应条件
sodium methylate in methanol; ethyl acetate
参考文献
Hoechst Aktiengesellschaft
Patent: US5359067 A1, 1994 ;
参考文献
Chi; Chen
Scientia Sinica (English Edition), 1957 , vol. 6, p. 477,484
Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 1483,1487; engl. Ausg. S. 1533, 1537
反应条件
1: methanol 2: H2O2 View Scheme
参考文献
Chi; Chen
Scientia Sinica (English Edition), 1957 , vol. 6, p. 477,484
Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 1483,1487; engl. Ausg. S. 1533, 1537
反应条件
1: 4-methoxy-5-methyl-2(1H)-pyrimidinone With lithium hydride in N,N-dimethyl-formamide T=60°C; 0.5 h; 2: dimethyl sulfate in N,N-dimethyl-formamide T=60°C; 48 h;
参考文献
Gambacorta, Augusto; Tofani, Daniela; Loreto, Maria Antonietta; Gasperi, Tecla; Bernini, Roberta
Tetrahedron, 2006 , vol. 62, # 29 p. 6848 - 6854
反应条件
1: 4-methoxy-5-methyl-2(1H)-pyrimidinone With lithium hydride in N,N-dimethyl-formamide T=60°C; 0.5 h; 2: diethyl sulphate in N,N-dimethyl-formamide T=60°C; 48 h;
参考文献
Gambacorta, Augusto; Tofani, Daniela; Loreto, Maria Antonietta; Gasperi, Tecla; Bernini, Roberta
Tetrahedron, 2006 , vol. 62, # 29 p. 6848 - 6854
反应条件
ammonia in methanol 1) With methanolic NH3 in autoclave at 120 deg C for 6 h;
参考文献
Holy, Antonin; Rosenberg, Ivan; Dvorakova, Hana
Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 8 p. 2190 - 2210
反应条件
1: 30 percent / Cs2CO3 / NaI / dimethylformamide 2: 89 percent / 0.1 N HCl / CH2Cl2 3: 98 percent / NaOAc*3H2O / methanol View Scheme
参考文献
Genevois-Borella; Florent; Monneret; Grierson
Tetrahedron Letters, 1990 , vol. 31, # 34 p. 4879 - 4882
反应条件
1: NH3 / methanol / 1) With methanolic NH3 in autoclave at 120 deg C for 6 h 2: 78 percent / 4-Dimethylaminopyridine / acetonitrile / 7 h / Heating View Scheme
参考文献
Holy, Antonin; Rosenberg, Ivan; Dvorakova, Hana
Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 8 p. 2190 - 2210
反应条件
1: 4-methoxy-5-methyl-2(1H)-pyrimidinone With lithium hydride in N,N-dimethyl-formamide
T=60°C; 0.5 h;
2: diethyl sulphate in N,N-dimethyl-formamide
T=60°C; 48 h;
参考文献
Gambacorta, Augusto; Tofani, Daniela; Loreto, Maria Antonietta; Gasperi, Tecla; Bernini, Roberta
Tetrahedron, 2006 , vol. 62, # 29 p. 6848 - 6854
