4-二甲胺基吡啶N-氧化物合成路线 （共 32 条）
反应条件
dihydrogen peroxide; trifluoroacetic acid in water T=0°C; 6.5 h; Reflux;
参考文献
Xuanzhu Pharmaco., Ltd.
Patent: EP2524917 A1, 2012 ;
Location in patent: Page/Page column 58 ;
反应条件
trifluoroacetic acid
反应条件
chiral ruthenium porphyrin complex catalyst in toluene T=-10°C; 48 h; Title compound not separated from byproducts.;
参考文献
Gross, Zeev; Ini, Santiago
Organic Letters, 1999 , vol. 1, # 13 p. 2077 - 2080
反应条件
1: HNO3; H2SO4 / 160 °C 2: AcOH; Fe / Heating 3: HNO3; H2SO4 / 20 °C View Scheme
参考文献
Xuanzhu Pharma Co., Ltd.
Patent: US2012/289497 A1, 2012 ;
反应条件
chiral ruthenium porphyrin complex catalyst in toluene T=-10°C; 48 h; Title compound not separated from byproducts.;
参考文献
Gross, Zeev; Ini, Santiago
Organic Letters, 1999 , vol. 1, # 13 p. 2077 - 2080
反应条件
1: HNO3; H2SO4 / 160 °C 2: AcOH; Fe / Heating 3: HNO3; H2SO4 / 20 °C 4: H2SO4 / 100 °C View Scheme
参考文献
Xuanzhu Pharma Co., Ltd.
Patent: US2012/289497 A1, 2012 ;
反应条件
chiral ruthenium porphyrin complex catalyst in toluene T=-10°C; 48 h; Title compound not separated from byproducts.;
参考文献
Gross, Zeev; Ini, Santiago
Organic Letters, 1999 , vol. 1, # 13 p. 2077 - 2080
反应条件
1.1: trichlorophosphate / 6 h / 100 °C 1.2: pH 8 - 9 / Cooling with ice 2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1.5 h 2.2: 1 h / 20 °C View Scheme
反应条件
chiral ruthenium porphyrin complex catalyst in toluene T=-10°C; 48 h; Title compound not separated from byproducts.;
参考文献
Gross, Zeev; Ini, Santiago
Organic Letters, 1999 , vol. 1, # 13 p. 2077 - 2080
反应条件
1: 73 percent / POCl3 / 4 h / Heating 2: 54 percent / Na / 7 h / Heating View Scheme
参考文献
Kaneko, Chikara; Uchiyama, Keiji; Sato, Masayuki; Katagiri, Nobuya
Chemical & Pharmaceutical Bulletin, 1986 , vol. 34, # 9 p. 3658 - 3671
