5-苯基-1H-吡嗪-2-酮合成路线 （共 15 条）
反应条件
sodium methylate in methanol
1 h; Heating;
参考文献
Nishio, Takehiko; Nakajima, Naoko; Kondo, Masaji; Omote, Yoshimori; Kaftory, Menahem
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 3 p. 391 - 396
反应条件
1: 54 percent / NaH; tetra-n-butylammonium iodide / tetrahydrofuran; dimethylformamide / 1 h / 70 °C
2: 100 percent / NaH / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
Mukaiyama, Harunobu; Nishimura, Toshihiro; Kobayashi, Satoko; Ozawa, Tomonaga; Kamada, Noboru; Komatsu, Yoshimitsu; Kikuchi, Shinji; Oonota, Hideki; Kusama, Hiroshi
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 868 - 885
反应条件
1: 54 percent / NaH; tetra-n-butylammonium iodide / tetrahydrofuran; dimethylformamide / 1 h / 70 °C
2: 100 percent / NaH / tetrahydrofuran / 1 h / 20 °C
3: 57 percent / anisole; trifluoroacetic acid; trifluoromethanesulfonic acid / 6 h / 40 °C
View Scheme
参考文献
Mukaiyama, Harunobu; Nishimura, Toshihiro; Kobayashi, Satoko; Ozawa, Tomonaga; Kamada, Noboru; Komatsu, Yoshimitsu; Kikuchi, Shinji; Oonota, Hideki; Kusama, Hiroshi
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 868 - 885
反应条件
1: POCl3, PCl5 / 1 h / 160 °C
2: 27 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1) r.t., overnight, 2) reflux, 3 h
View Scheme
参考文献
Ohta, Akihiro; Watanabe, Tokuhiro; Akita, Yasuo; Yoshida, Maki; Toda, Suzumi; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1061 - 1067
反应条件
1: POCl3, PCl5 / 1 h / 160 °C
2: 25 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1) r.t., overnight, 2) reflux, 3 h
View Scheme
参考文献
Ohta, Akihiro; Watanabe, Tokuhiro; Akita, Yasuo; Yoshida, Maki; Toda, Suzumi; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1061 - 1067
