thionyl chloride

in hydrogenchloride; methanol; diethyl ether

in methanol

1: With sodium hydroxide in tetrahydrofuran; water T=20°C; 2: With hydrogenchloride in water

triethylamine in 1,4-dioxane; methanol; water 3 h; Ambient temperature;

暂无反应条件数据

TEA in 1,4-dioxane; methanol; water 3 h;

1: acetyl chloride / 8 h / Heating 2: 90 percent / triethylamine / CH2Cl2 / 12 h 3: 1.) pyridinium p-toluenesulfonate, 2.) lithium borohydride / 1.) dichloromethane, room temperature 3 h, 2.) THF 4: 7.5 g / triethylamine / CH2Cl2 / 1 h / 0 °C 5: 62 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / Heating 6: 60 percent / acetic acid / H2O / 1.5 h / Heating View Scheme

1: 82.5 percent / aq. NaOH / tetrahydrofuran / Ambient temperature 2: 92.4 percent / dioxane; diethyl ether / 0.25 h / 5 °C 3: 93.9 percent / Ph3P, DEAD / tetrahydrofuran / 42 h / Ambient temperature 4: 97.4 percent / LiBH4 / tetrahydrofuran / Ambient temperature 5: 87.7 percent / Et3N / CH2Cl2; tetrahydrofuran / 43 h / Ambient temperature 6: 41.7 percent / triphenylphosphine, DEAD / tetrahydrofuran / 21.6 h / Ambient temperature 7: 97.3 percent / ammonia / methanol / 60 h / 85 - 87 °C 8: 0.19 percent / trifluoroacetic acid / 1.25 h / Ambient temperature View Scheme

thionyl chloride T=0°C;