顺式-4-羟基-D-脯氨酸合成路线 （共 35 条）
反应条件
1: With acetic anhydride in acetic acid 5.5 h; Heating; 2: With hydrogenchloride 3 h; Heating;
参考文献
Heindl, Cornelia; Huebner, Harald; Gmeiner, Peter
Tetrahedron Asymmetry, 2003 , vol. 14, # 20 p. 3141 - 3152
反应条件
hydrogenchloride 2 h; Heating;
参考文献
Dalla Croce, Piero; La Rosa, Concetta
Tetrahedron Asymmetry, 2002 , vol. 13, # 2 p. 197 - 201
反应条件
1: H2 / Pd(OH)2 / ethanol / 5 h / 1861.7 Torr / Ambient temperature 2: 1M NaOH / 2 h View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 7, # 3 p. 825 - 830
反应条件
1: With hydrogenchloride in 1,4-dioxane T=20°C; 19 h; 2: With TEA in ethanol
参考文献
Bulletin of the Chemical Society of Japan, , vol. 75, # 11 p. 2517 - 2525
反应条件
1.1: 84 percent / DMAP; TEA / CH2Cl2 / 20 °C 2.1: 100 percent / imidazole / dimethylformamide / 20 °C 3.1: 100 percent / 1.5M HCl / ethanol / 2 h / 20 °C 4.1: 59 percent / Ph3P; DEAD / CH2Cl2; toluene / 48 h / 0 °C 5.1: 100 percent / H2 / 5 percent Pd/C / ethanol / 24 h / 20 °C 6.1: 90 percent / TBAF / tetrahydrofuran / 20 °C 7.1: 1.0M LiOH aq. / ethanol / 2 h / 20 °C 8.1: 2M HCl / dioxane / 19 h / 20 °C 8.2: TEA / ethanol View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 75, # 11 p. 2517 - 2525
反应条件
1.1: 100 percent / imidazole / dimethylformamide / 20 °C 2.1: 100 percent / 1.5M HCl / ethanol / 2 h / 20 °C 3.1: 59 percent / Ph3P; DEAD / CH2Cl2; toluene / 48 h / 0 °C 4.1: 100 percent / H2 / 5 percent Pd/C / ethanol / 24 h / 20 °C 5.1: 90 percent / TBAF / tetrahydrofuran / 20 °C 6.1: 1.0M LiOH aq. / ethanol / 2 h / 20 °C 7.1: 2M HCl / dioxane / 19 h / 20 °C 7.2: TEA / ethanol View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 75, # 11 p. 2517 - 2525
反应条件
hydrogenchloride 17 h; Heating;
参考文献
Renaud, Philippe; Seebach, Dieter
Helvetica Chimica Acta, 1986 , vol. 69, p. 1704 - 1710
反应条件
1: H2 / PtO2 2: 98.0 percent Turnov. / aq. HCl / 16 h / Heating View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 343, # 6-7 p. 587 - 590
反应条件
1.1: 1.0M LiOH aq. / ethanol / 2 h / 20 °C 2.1: 2M HCl / dioxane / 19 h / 20 °C 2.2: TEA / ethanol View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 75, # 11 p. 2517 - 2525
反应条件
hydrogenchloride 16 h; Heating;
参考文献
Advanced Synthesis and Catalysis, , vol. 343, # 6-7 p. 587 - 590
