3,5-二溴-4-甲氧基吡啶合成路线 （共 3 条）
反应条件
1: methanol With sodium hydride in tetrahydrofuran T=0°C; 0.25 h; 2: 3,4,5-tribromo-pyridine in tetrahydrofuran T=20°C; 19 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; AUSTIN, Joel, Francis; SHARMA, Lisa, S.; BALOG, James, Aaron; HUANG, Audris; VELAPARTHI, Upender; DARNE, Chetan, Padmakar; SAULNIER, Mark, George
Patent: WO2012/15723 A1, 2012 ;
Location in patent: Page/Page column 93 ;
WO 2012/015723 A1
反应条件
1.1: N-bromosuccinmide / tetrachloromethane / 24 h / 20 °C / Darkness 2.1: phosphorus pentabromide / 3 h / 180 °C / sealed tube 3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C 3.2: 19 h / 20 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; AUSTIN, Joel, Francis; SHARMA, Lisa, S.; BALOG, James, Aaron; HUANG, Audris; VELAPARTHI, Upender; DARNE, Chetan, Padmakar; SAULNIER, Mark, George
Patent: WO2012/15723 A1, 2012 ;
WO 2012/015723 A1
反应条件
1.1: phosphorus pentabromide / 3 h / 180 °C / sealed tube 2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C 2.2: 19 h / 20 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; AUSTIN, Joel, Francis; SHARMA, Lisa, S.; BALOG, James, Aaron; HUANG, Audris; VELAPARTHI, Upender; DARNE, Chetan, Padmakar; SAULNIER, Mark, George
Patent: WO2012/15723 A1, 2012 ;
WO 2012/015723 A1
