2-氨基-3-(4-溴-1H-吲哚-3-基)丙酸合成路线 （共 5 条）
反应条件
1: 96 percent 2: 1.) t-BuLi, 2.) Br(CH2)2Br / 1.) Et2O 3: 99 percent / TBAF / tetrahydrofuran / 4 h 4: 92 percent / NaOH / toluene / 24 h / Heating 5: 1.) NaOH, 2.) AcOH, 3.) 3M HCl / 1.) THF, H2O, room temperature, 24 h, 2.) reflux, 24 h, 3.) reflux, 24 h View Scheme
参考文献
Hurt, Clarence R.; Lin, Ronghui; Rapoport, Henry
Journal of Organic Chemistry, 1999 , vol. 64, # 1 p. 225 - 233
反应条件
1: 92 percent / NaOH / toluene / 24 h / Heating 2: 1.) NaOH, 2.) AcOH, 3.) 3M HCl / 1.) THF, H2O, room temperature, 24 h, 2.) reflux, 24 h, 3.) reflux, 24 h View Scheme
参考文献
Hurt, Clarence R.; Lin, Ronghui; Rapoport, Henry
Journal of Organic Chemistry, 1999 , vol. 64, # 1 p. 225 - 233
反应条件
1: 1.) t-BuLi, 2.) Br(CH2)2Br / 1.) Et2O 2: 99 percent / TBAF / tetrahydrofuran / 4 h 3: 92 percent / NaOH / toluene / 24 h / Heating 4: 1.) NaOH, 2.) AcOH, 3.) 3M HCl / 1.) THF, H2O, room temperature, 24 h, 2.) reflux, 24 h, 3.) reflux, 24 h View Scheme
参考文献
Hurt, Clarence R.; Lin, Ronghui; Rapoport, Henry
Journal of Organic Chemistry, 1999 , vol. 64, # 1 p. 225 - 233
反应条件
1: 99 percent / TBAF / tetrahydrofuran / 4 h 2: 92 percent / NaOH / toluene / 24 h / Heating 3: 1.) NaOH, 2.) AcOH, 3.) 3M HCl / 1.) THF, H2O, room temperature, 24 h, 2.) reflux, 24 h, 3.) reflux, 24 h View Scheme
参考文献
Hurt, Clarence R.; Lin, Ronghui; Rapoport, Henry
Journal of Organic Chemistry, 1999 , vol. 64, # 1 p. 225 - 233
反应条件
hydrogenchloride; sodium hydroxide; acetic acid 1.) THF, H2O, room temperature, 24 h, 2.) reflux, 24 h, 3.) reflux, 24 h; Yield given. Multistep reaction;
参考文献
Hurt, Clarence R.; Lin, Ronghui; Rapoport, Henry
Journal of Organic Chemistry, 1999 , vol. 64, # 1 p. 225 - 233
