(3-溴吡啶-4-基)氨甲酸叔-丁基酯合成路线 （共 4 条）
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=20°C; 48 h;
参考文献
Hudyma, Thomas W.; Zheng, Xiaofan; He, Feng; Ding, Min; Bergstrom, Carl P.; Hewawasam, Piyasena; Martin, Scott W.; Gentles, Robert G.
Patent: US2006/46983 A1, 2006 ;
Location in patent: Page/Page column 186 ;
反应条件
1: With tert.-butyl lithium in tetrahydrofuran; pentane T=-78 - -15°C; Metallation; lithiation; 3.5 h; 2: With ethylene dibromide in tetrahydrofuran; pentane T=-78 - 20°C; Bromination; 2 h;
参考文献
Spivey, Alan C.; Fekner, Tomasz; Spey, Sharon E.; Adams, Harry
Journal of Organic Chemistry, 1999 , vol. 64, # 26 p. 9430 - 9443
反应条件
1.1: 38.6 g / CH2Cl2; H2O / 0.42 h / 20 °C 2.1: t-butyllithium / tetrahydrofuran; pentane / 3.5 h / -78 - -15 °C 2.2: 85 percent / 1,2-dibromoethane / tetrahydrofuran; pentane / 2 h / -78 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 26 p. 9430 - 9443
反应条件
1.1: 38.6 g / CH2Cl2; H2O / 0.42 h / 20 °C 2.1: t-butyllithium / tetrahydrofuran; pentane / 3.5 h / -78 - -15 °C 2.2: 85 percent / 1,2-dibromoethane / tetrahydrofuran; pentane / 2 h / -78 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 26 p. 9430 - 9443
